@article {1385, title = {Exploring the Therapeutic Potential of Plectranthus amboinicus: LC-MS Profiling and Molecular Docking Insights}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {552-561}, type = {Original Article}, chapter = {552}, abstract = {

Introduction: Plectranthus amboinicus is noted for its diverse phytochemical profile, which includes various semi-polar compounds and significant secondary metabolites. These compounds may offer therapeutic benefits for diabetes management. Objectives: This study investigates the anti-diabetic potential of phytoconstituents from Plectranthus amboinicus by utilizing both Liquid Chromatography-Mass Spectrometry (LC-MS) and molecular docking techniques. Materials and Methods: The study employed LC-MS to identify and analyze the phytoconstituents in Plectranthus amboinicus, providing detailed separation and detection of its bioactive compounds. Molecular docking simulations were conducted to evaluate how these phytoconstituents interact with diabetes-related target proteins, specifically alpha-amylase and alpha-glucosidase. The docking process involved 2 main steps: pose prediction to determine the ligand{\textquoteright}s conformation and positioning and scoring to assess binding affinity. Results: LC-MS analysis identified several key bioactive compounds in Plectranthus amboinicus. Molecular docking studies showed that these compounds interact specifically with alpha-amylase and alpha-glucosidase, indicating potential effectiveness in inhibiting these enzymes. Conclusion: The integration of LC-MS and molecular docking provides a robust methodology for discovering and characterizing potential anti-diabetic agents in Plectranthus amboinicus. The present investigation involves the LC-MS analysis and in silico study that aims to investigate the interaction between alpha-amylase, alpha-glucosidase, and the compounds (ligands) derived from Coleus amboinicus. This study underscores the therapeutic potential of its phytoconstituents and highlights the importance of combining analytical and computational approaches in the development of new diabetes treatments.

}, keywords = {Alpha-amylase, Alpha-glucosidase, Diabetes, Drug Discovery, LC-MS, Molecular docking, Phytoconstituents, Plectranthus amboinicus}, doi = {10.5530/pres.20251961}, author = {Shaeena MH and Bharathi DR} } @article {1414, title = {The Ocean{\textquoteright}s Treasure Trove: Bioactive Compounds from Sea Sponges}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {452-461}, type = {Review Article}, chapter = {452}, abstract = {

Sea sponges are among the oldest living creatures on Earth that have evolved complex chemical defenses to thrive in the ocean{\textquoteright}s competitive environment. These marine animals have developed an impressive array of bioactive compounds with therapeutic applications. This article explores bioactive compounds derived from sea sponges, showcasing their remarkable therapeutic potential. The article begins by introducing the fascinating world of sea sponges, highlighting their unique biology and ecology. We then delve into the various bioactive compounds isolated from sea sponges. The review highlights the anticancer properties of sea sponge-derived compounds demonstrating their potential in cancer treatment. We also explore their antimicrobial and anti-inflammatory activities, showcasing their potential in combating infectious diseases and inflammatory disorders. The article further discusses the challenges and opportunities in harnessing the bioactive potential of sea sponges. This review serves as a comprehensive resource for researchers, scientists, and students interested in marine biomedicine and natural product drug discovery.

}, keywords = {Anti-inflammatory, anticancer, Bioactive compounds, Drug Discovery, Marine biomedicine, Sea sponges, Therapeutic potential}, doi = {10.5530/pres.20252085}, author = {Sheetal Sadguru Samant and Anvay Ashok Satpute and Mikhil Prasad Mayekar and Shamita Shamsundar Loke and Shweta Nitin Bhatkar and Mohammad Saad Golandaj and Tanvi Deepak Rawool and Vijay Arjun Jagtap} }