@article {1431, title = {In silico Insights Into the Medicinal Potential of Phyllanthus amarus: Phytoconstituents and Therapeutic Applications}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {707-718}, type = {Review Article}, chapter = {707}, abstract = {

Phyllanthus amarus is a globally distributed herb. Over the 3000 years, it has been used as traditional medicine. This plant is articulated in different languages differently like in Hindi- Bhuyiavla, Jangli amla, Marathi- Bhuivali, Bihari- Muikoa, Sanskrit- Bhumyaamlaki, etc. It is an herb that can grow between 30 and 75 cm tall annually. Worldwide, Phyllanthus amarus is a plant widely distributed in tropical and subtropical areas. In Indian Ayurveda, the Phyllanthus amarus is used as a traditional medicine. It treats various diseases such as cough, diuretics, menstrual problems, stomach, kidney, etc. Scientific research said that Phyllanthus amarus exhibits potency against multiple diseases including diabetes, arthritis, inflammation, convulsion, neuroactive, hepatoprotective, nephroprotective, vasoconstriction, etc. Phyllanthus amarus has several secondary metabolites such as tannin, flavonoid, saponin, alkaloids, terpenoids, lignans, sterols, and volatile oils. Aqueous and non-aqueous extraction of Phyllanthus amarus and isolation of chemical compounds such as securinine, phyllanthine, rutin, quercitrin, amariin, geraniin, hypophyllanthins, isonirtetralin, amarosterol-A, phytol, phenazine, ursolic-acid, isolintetralin, etc. These compounds are responsible for pharmacological activity such as anti-cancer, antibacterial, analgesic, antifungal, antioxidant, antiviral, contraceptive, anti-inflammatory, etc. On the other hand, molecular docking is a potent computational process for studying molecular interactions from the drug discovery perspective. It is applied to forecast the orientation in which small drug molecules will bind to their protein targets, predicting their affinity and activity.

}, keywords = {Medicinal potential, Molecular docking, Phyllanthus amarus, Phytoconstituent}, doi = {10.5530/pres.20252168}, author = {Ayushi Varshney and Pawan Kumar Gupta and Prashant Kumar and Shashi Bhooshan Tiwari} } @article {1249, title = {Unveiled the Pharmacological Attributes of Pupalia lappacea: An Unexplored Plant}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {449-456}, type = {Review Article}, chapter = {449}, abstract = {

Introduction: Pupalia lappacea which is commonly referred to as forest burr found everywhere in the world. In this review article, we will discuss the traditional use and photochemistry of plants. Its traditional uses have been investigated by various scientists whose results came out to be effective against various diseases. Pupalia lappacea consists of various phytochemicals named stearic acid, stigmasterol, formic acid, 1-methyl ethyl ester, etc. In vitro and in vivo studies that have been investigated thus far prove that this plant posse{\textquoteright}s great therapeutic potential including anti-microbial, antioxidant, anti-inflammatory, anti-diarrheal, anti-nociceptive and anti-pyretic, anti-plasmodium, anti-hypolipidemic, antidiabetic activity which can be further explored for its clinical utility. Materials and Methods: This article comprises data from a research article published on various search engines including Google Scholar, PubMed, ScienceDirect, Scopus, etc., Data is also collected via textbooks, reference books, review papers and ancient texts. Objectives: This review aims to gather all updated pharmacological investigations that have been done on Pupalia lappacea together. In short, the main aim was to provide an updated review of Pupalia lappacea to the researchers who further want to explore its potency and efficacy. Results: All the documents related to the plant were studied thoroughly and it was concluded that this plant possesses a great therapeutic potential and can be clinically explored.

}, keywords = {Anti-inflammatory, Anti-microbial, Antioxidant, Phytoconstituent, Pupalia lappacea}, doi = {10.5530/pres.16.3.54}, author = {Poonam Dorata and Harsh Goswami and Pooja and Tarun Kumar and Manisha Pandey} }