@article {1290, title = {HPLC Based Metabolomic Fingerprint Profiling as A Comprehensive Quality Assessment Tool, Why Not for Standardization of Ayurvedic Herbs and Formulations?}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {677-687}, type = {Review Article}, chapter = {677}, abstract = {

A global resurgence and rampant increase in the usage of herbal medicines has led to malpractices in the absence of adequate regulatory control to meet the growing demand. To ensure quality and hence efficacy, of these drugs is the prime concern. The reason for poor regulatory control over herbal drugs is lack of adequate and accepted methods for evaluating them. In spite of technological advancement in analytical methods and instruments, standardization of herbal drugs is still an elusive goal. High Performance Liquid chromatography based metabolomic fingerprint profiling approach for different herbs and herbal formulations can be answer to this. HPLC based this approach is robust, precise, quantitative, easy to use, thus safeguarding that herbal medicine can be authenticated for their quality evaluation. In this review an introduction is given that why the quality evaluation of herbal medicine is important by means of HPLC based metabolomics. This approach includes extraction, chromatographic analysis and chemometric analysis to the produced chromatographic data. Various studies based on this approach are discussed that can be the torch light and helpful to keep the Legacy of intangible ayurvedic culture intact, that why and how this approach should be adopted.

}, keywords = {Ayurveda, Chemometric, Fingerprint, HPLC, Metabolomics, Quality}, doi = {10.5530/pres.16.4.79}, author = {Nikunj Patel and Khushi Dave and Rinkal Patel and Kunjal Vegad and Niranjan Kanaki} } @article {1118, title = {FTIR Based Metabolomics Profiling and Fingerprinting of Some Medicinal Plants: An Attempt to Develop an Approach for Quality Control and Standardization of Herbal Materials}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {163-167}, type = {Original Article}, chapter = {163}, abstract = {

Background: The medicinal plants are used for their various therapeutic effects in treatment and prevention of various diseases. Recently herbal medicines are playing an important role in health care across the world. With increased global acceptance of the herbal drugs proper quality control of the herbal medicines have become important to ensure the safety and efficacy of the herbal products. Herbal-based FT-IR metabolomics is a suitable method for quick and reliable quality control and metabolite profiling to ensure quality and reproducibility of herbal medicine. The FT-IR analysis is relatively easy to use, reproducible, non-destructive, and can be used for quick analysis and verification of the herbal medicines. Materials and Methods: In the present work FTIR fingerprint was obtained for extracts and powders of some of the selected medicinal plants. The samples were characterized by using FTIR metabolomics profiling on basis of the diagonostic peaks. Results: Various functional groups, such as phenolics (-OH), carbonyl (C=O), aldehyde (CH=O), ether (C-O-C), aromatic (C=C), and alkyl groups -CH, were identified. Various metabolites e.g. liquiritin, glycyrrhizic acid, glabridin, shogoal, piperine were successfully identified on basis of the diagonostic FTIR peaks. Conclusion: FTIR was found to be a simple, rapid and convenient analytical method and fingerprinting technique for quality control of herbal materials.

}, keywords = {Fingerprinting, FTIR, Medicinal plants, Metabolomics, Quality control, Secondary metabolites}, doi = {10.5530/097484900288}, author = {Manas Ranjan Sahoo and Marakanam Srinivasan Umashankara} }