@article {1206, title = {Anti-arthritic and Anti-inflammatory Activity of Ayurvedic Polyherbal Formulation in Laboratory Animals}, journal = {Pharmacognosy Research}, volume = {16}, year = {2023}, month = {December 2023}, pages = {110-117}, type = {Original Article}, chapter = {110}, abstract = {

Background: RD/M.ph.AA-01 is an Ayurvedic polyherbal formulation, developed for amavata, which is associated with chronic inflammatory autoimmune diseases. Objectives: The study was planned to evaluate the anti-arthritic and anti-inflammatory activity of RD/M.ph.AA-01 in laboratory animals. Materials and Methods: Anti-arthritic activity of RD/M.ph.AA-01 was evaluated at 270 and 405 mg/kg doses against Complete Freund{\textquoteright}s Adjuvant (CFA)-induced arthritis. Anti-inflammatory activity was studied using cotton pellet granuloma and formalin-induced edema in rat models. The effect of topical application of RD/M.ph.AA-01 on Croton oil ear edema in mice was also investigated. Results: Arthritis induction caused a significant (p\<0.05) alteration in paw size, hematology, serum parameters, edematous tissue parameters, lipid peroxidation in the liver and histopathology of joints. These alterations were significantly (p\<0.05) prevented by treatment with RD/M.ph.AA-01. In the cotton pellet granuloma, RD/M. ph.AA-01 supplementation caused significant (p\<0.05) improvement in the weight of granuloma tissue, serum parameters, lipid peroxidation in the liver and histopathological changes in granuloma tissue. A significant (p\<0.05) improvement in paw size, serum parameters and liver lipid peroxidation were observed by RD/M.ph.AA-01 treatment in the formalin-induced edema model. The RD/M.ph.AA-01 also significantly (p\<0.05) suppressed Croton oil-induced ear edema. Conclusion: These findings showed that RD/M.ph.AA-01 possesses potent anti-arthritic and anti-inflammatory activity.

}, keywords = {Anti-arthritic, Anti-inflammatory, Ayurvedic polyherbal formulation.}, doi = {10.5530/pres.16.1.13}, author = {Chandrasekar Sandanapalli Basavarajaiah and Anil Tukaram Pawar and Harisha Ramappa and Vani Setty} } @article {1152, title = {Therapeutic Potential of Alstonia scholaris Latex in the Management of Inflammatory Diseases: An in vitro Approach}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {478-483}, type = {Original Article }, chapter = {478}, abstract = {

Background: The different parts of Alstonia scholaris (AS) viz. leaf, bark root, and latex are used traditionally to treat pain, swelling, stiffness, immune deficiency, malaria, ulcer, and arthritis. The traditional healers in Dhemaji district of Assam prescribe raw AS latex for topical treatment of inflammatory diseases. The unique feature of this study is that the AS latex has been evaluated scientifically for the first time for its anti-inflammatory properties. Objectives: The present investigation evaluates the anti-inflammatory potential of the AS latex in arthritis using in vitro assays. Materials and Methods: Anti-arthritic potential of AS latex was evaluated using in vitro assays of bovine serum albumin (BSA) denaturation, egg albumin denaturation, and human red blood cell (HRBC) membrane stabilization. Results: It was observed that the standard diclofenac sodium and the AS latex showed good anti-arthritic potential. In BSA denaturation method, the latex, and diclofenac sodium showed 71.59\% and 85.23\% inhibition of proteinase enzyme at 250 μg/mL, respectively. In the egg albumin denaturation method, the latex, and standard showed the maximum percentage of inhibition of protein denaturation of 70.42\% and 81.32\%, respectively, at 250 μg/mL. In the HRBC membrane stabilization model, the latex produced considerable anti-arthritic potential in a concentration{\textendash}dependent manner. At 250 μg/ mL in hypotonic solution, latex, and diclofenac sodium showed 68.77\% and 72.12\% membrane stabilization, respectively. Conclusion: The present investigation proved the antiarthritic activity of AS latex. It may also be used in the management of other inflammatory diseases.

}, keywords = {Alstonia scholaris, Anti-arthritic, Anti-inflammatory, in vitro., Latex}, doi = {10.5530/pres.15.3.049}, author = {Bapan Banik and Malay Kumar Das} } @article {1077, title = {A Current Pharmacological Impacts and Perspective of Hybanthus enneaspermus (Linn.) F. Muell}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {342-349}, type = {Review Article}, chapter = {342}, abstract = {

Medicine relies heavily on the use of medicinal plants. In terms of their pharmacology, they showed a broad spectrum of traits. All but a few of the medicinal plants in India are naturally rich in chemicals. An infinite number of potent phytochemicals can be synthesised by these plants. It is a tropical and subtropical shrub of the Hybanthus enneaspermus (L) famuell family. Asthma, cough, and epilepsy are all treated with the herb in ayurvedic literature as side effects of its usage. For steroids, sugars, alkaloids, polyphenols, catechins, tannins, anthraquinones, and amino acids, phytochemical analysis of Hybanthus enneaspermus achieved good quality. Alkaloids, terpenoids, tannins and glycosides are only some of the many phytochemical elements found in the plant. We examined the plant{\textquoteright}s phytopharmacological properties, including as anti-microbial and antioxidant properties as well as its effects on diabetes and arthritic conditions. We also looked at its anti-allergic and anti-convulsant properties. The active chemicals extracted from this valued herb have the potential to be used in drug development research because of the plant{\textquoteright}s wide range of pharmacological activity.

}, keywords = {Anti-allergic, Anti-arthritic, Anti-convulsant, Anti-diabetic, Anti-fertility, Anti-microbial, Antioxidant, Hybanthus enneaspermus}, doi = {10.5530/pres.14.4.51}, author = {Ananthapalpu Krishnan Nadar Ramya and Rengasamy Devika} }