@article {1082, title = {Development of a Gastroretentive Polyherbal Formulation and its Standardization}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {379-390}, type = {Original Article}, chapter = {379}, abstract = {

Background: Phytopharmaceuticals within the shape of the entire herb, plant parts, or separated bioactive constituents have been utilized broadly in therapeutics since antiquated times till date. The appealing use of drugs of the natural root has driven the requirement for standardization as per the WHO guidelines. Objectives: The main aim of the existing study was to formulate polyherbal gastroretentive capsules by using Carbopol 934 and 971P in different concentration ranges to get desired buoyancy rate. Materials and Methods: The prepared formulation was characterized by physico-chemical parameters and pharmaceutical quality control tests. Standard procedures were used to estimate the organoleptic properties, extractive values, and ash values of the crude drugs used in formulations. Extraction was carried out using Soxhlation followed by preliminary phytochemical evaluation and HPTLC fingerprinting of the extracts. The extracts were formulated into a gastroretentive polyherbal capsule and assessed for physical parameters. Results: The phytochemical assessment established the presence of flavonoids, alkaloids, saponins, steroids, and glycosides. Rf values obtained from the HPTLC studies of the extracts signified the presence of important phytoconstituents such as Shogaols, 6-Gingerol, 8-Gingerol, Glycyrrhizin, Andrographolides, Marmelosin, and Conessine. Percent Carr{\textquoteright}s consolidation index ranging from 8.111 {\textpm} 0.157 to 8.827 {\textpm} 0.186, Hausner{\textquoteright}s ratio between 1.088 {\textpm} 0.002 to 1.097 {\textpm} 0.002, and angle of repose below 30 are indicative of excellent flow property of the granules. Conclusion: The gastroretentive capsules PHF4 containing granules formulated using 75 mg Carbopol 971P showed a buoyancy effect of more than 24 hr with desired structural integrity.

}, keywords = {Extraction, HPTLC fingerprinting, Polyherbal formulation, Standardization}, doi = {10.5530/pres.14.4.56}, author = {Manish Kumar Gupta and Medha Amol Khade and Birendra Srivastava and Supriya Rajesh Hyam and Prashant Basappa Gurav} } @article {1081, title = {Exploration of Phytopharmacognostical Study of Ipomoea obscura (Linn.) Ker Gawl}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {369-378}, type = {Original Article}, chapter = {369}, abstract = {

Background: Ipomoea obscura, also known as {\textquotedblleft}Lakshmanvel{\textquotedblright} in India, is a member of the Convolvulaceae family. Early studies were mostly concerned with early phytochemical analysis, with only a few focusing on detailed phytochemical analysis. Objectives: The aim of this study was to identify the phytochemical and pharmacognostic characteristics of I. obscura leaves. Materials and Procedures: The methanolic extracts were separated into flavonoids and phytosterol by column chromatography, which were subsequently examined by spectroscopy and HPTLC methods. Results: According to this research{\textquoteright}s findings, I. obscura leaves may be a good source of phytochemicals such flavonoids (Kaempferol and quercetin), terpenids (β-sitosterol and lupeol), which were identified by HPTLC fingerprinting, FTIR NMR, and UV spectroscopy. Conclusion: The spectroscopical data and HPTLC fingerprinting profile for the plant of interest would hopefully aid herbal medicine researchers in developing additional herbal medications that require the specific ingredient or extract.

}, keywords = {Characterization, HPTLC fingerprinting, Isolation, Microscopical study, Phytochemical investigation, Quantitative estimation}, doi = {10.5530/pres.14.4.55}, author = {Poonam Shinde and Rajendra Bhambar and Pankaj Patil and Khanderao Jadhav and Prashant Malpure} }