@article {1080, title = {Development and Assessment of Phytophospholipid Nanovesicular Systems for Treatment of Diabetic Neuropathy}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {360-368}, type = {Original Article}, chapter = {360}, abstract = {

Background: Diabetic neuropathy (DN) is the most prevalent and problematic consequence of diabetes mellitus, with the highest rates of morbidity and death, as well as a significant financial burden on diabetes treatment. Aside from commercially available formulations, substantial research on herbal-based natural therapies to treat hyperglycemia and related consequences is underway. Objectives: The major aim of the study was to use an ethosomal gel to improve transdermal penetration of Curcuma longa and Boswellia serrata and to overcome the challenges of low transdermal drug delivery permeability. Materials and Methods: Curcuma longa and Boswellia serrata loaded ethosomes were made using a cold process with various amounts of ethanol and soya lecithin, and were improved based on entrapment efficiency, vesicular size, and ex-vivo investigations. Results: The optimized ethosomal formulation was then put into a gel and evaluated. Ex-vivo tests were conducted with Curcuma longa and Boswellia serrata ethosomal gels, which were compared to plain gel. The ethosomal system produced vesicles with sizes ranging from 1 to 100 nm, a spherical, smooth surface, and a maximum entrapment efficiency of Ne9. A modified ethosomal system (Ne9) was introduced into the gel and studied further. Conclusion: According to the findings, the ethosomal gel has a lot of potential for transdermal Curcuma longa and Boswellia serrata administration.

}, keywords = {Boswellia serrata, Curcuma longa, Drying studies, Ethosomal gel, Ethosomes, Ex-vivo studies}, doi = {10.5530/pres.14.4.54}, author = {Gaurav Tiwari and Deepa Yadav and Bhuwanendra Singh and Abhitendra Kumar and Pranay Wal and Ruchi Tiwari} } @article {1094, title = {Development of a Solid Self-emulsifying Drug Delivery System of Boswellia serrata}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {429-441}, type = {Original Article}, chapter = {429}, abstract = {

Background: Self-emulsifying drug delivery system (SEDDS) and solid-SEDDS of Boswellia serrata extract (BSE) was aimed at overcoming the problems of poor solubility and bioavailability. Materials and Methods: The formulation strategy included a selection of oil phase, surfactant and co-surfactant based on qualitative and quantitative saturated solubility studies. A ternary phase diagram was constructed to identify the self-emulsifying region using water uptake studies. Pseudoternary phase diagrams were plotted using 1:1, 2:1 and 3:1 ratios of surfactant and co-surfactant to identify the maximum micro-emulsification region. The prepared formulations of SEDDS were evaluated for their physical appearance, stability, drug content, and globule size determination. Solid-SEDDS were prepared by adsorption technique using mannitol (4.5\% w/w) and were evaluated for physical appearance, stability, drug content, and globule size. In-vitro studies were performed to compare the release of solid drugs, SEDDS and S-SEDDS. Results: The formulation containing Boswellia serrata (200 mg), Capmul MCM C8 (15\% w/w), Tween 20 (33.333\% w/w), Transcutol HP (16.666\% w/w) was concluded to be optimized. The release pattern was signified more than 80\% release in 30 min in case of S-SEDDS and SEDDS, and 40\% release after 120 min in case of solid drug. Solid-SEDDS may be considered a better solid oral dosage form as solidified formulations are more ideal than liquid ones in terms of their stability. Conclusion: Results suggest the potential use of SEDDS and solid-SEDDS to improve the dissolution and hence oral bioavailability of poorly water-soluble drugs like Boswellia serrata through oral route.

}, keywords = {Bioavailability, Boswellia serrata, Phase diagram, Solid-self-emulsifying drug delivery system}, doi = {10.5530/pres.14.4.63}, author = {Vidhi Bhatia and MS Arohi Paul} }