@article {1353, title = {Study of in silico and in vitro Anthelmintic Activity of Ethanolic Extract of Artemisia pallens Wall Ex. DC}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {143-153}, type = {Original Article}, chapter = {143}, abstract = {

Background: Helminths, a disease that affects all ages, are being treated with medicinal herbs such as Artemisia pallens Wall. ex DC, a traditional plant material with phytomedicinal properties. Objectives: The study assesses the anthelmintic activity of ethanolic plant material extract against common gastrointestinal helminths and explores its potential as an alternative or complementary treatment for parasitic infections. Materials And Methods: Indian adult earthworm Pheritima posthuma was employed to screen anthelmintic activity. Worms were exposed to different concentration 10 mg/mL, 20 mg/mL, 50 mg/mL, 80 mg/mL and 100 mg/mL concentrations of extract and standard drug, albendazole. Molecular docking for the observation of compounds which had higher activities towards the NADH-Fumarate reductase enzyme. From the database, the compounds with higher docking fitness scores determined using the Auto Dock software version 1.5.6. Further, the ADME/T profiling was done on Swiss ADME Analysis and also on pkCSM software tool. Results: Preliminary phytochemical analysis of EEAP indicated the presence of alkaloids, flavonoids, tannins, phenols, terpenoids. The anthelmintic potential of A. pallens extract, which showed strong antihelminthic activity in combination with adult Pheritima posthuma that produced paralysis and death at an earlier period as compared to albendazole, while the molecular docking study found good binding scores in the range of -5.15 kcal/mol to -9.6 kcal/mol with the fumarate reductase enzyme. Conclusion: The study confirmed the potential anthelmintic activity of Artemisia pallens. Wall extract, with compounds showing favorable binding scores indicating potential for forthcoming clinical investigations.

}, keywords = {Anthelmintic, Artemisia pallens, AutoDock, Fumarate reductase, Pheretima posthuma}, doi = {10.5530/pres.20251960}, author = {Madhivardhana. P and J. Vidhya Bharathy and S. Ajay Karthikeyan} } @article {115, title = {Pharmacognostical Standardization, Phytochemical Investigation, and Anthelminthic Activity of Arisaema propinquum Schott Rhizomes}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {May 2020}, pages = { 181-185}, type = {Original Article}, chapter = {181}, abstract = {

Ethnopharmacology: Arisaema propinquum Schott (Araceae) is commonly known as cobra lily. Traditionally, the rhizomes were used as vermifuge, in rheumatism, as stomachache, and in snake bites. Objectives: The present study was designed to evaluate the pharmacognostical parameters and anthelminthic activity of A. propinquum rhizomes. Materials and Methods: The rhizomes of A. propinquum Schott was collected, shade dried and then powdered, and then evaluated for pharmacognostic parameters such as macro- and microscopical characters, physico-chemical parameters, and phytochemical analysis using standard procedures. Anthelminthic activity of the extracts was elevated against Pheretima posthuma. Results: The rhizomes are light brown in color with pungent odor and astringent taste. Transverse section of rhizomes showed intercellular schizogenous cavities, xylem vessels, phloem vessels, and parenchymatous cells. Phytochemical screening of the extracts reveals the presence of alkaloids, carbohydrates, cardiac glycosides, coumarins, proteins, amino acids, phenols, tannins, flavonoids, saponins, steroids, and terpenoids. Physiochemical parameters including ash values showed 6.32\% total ash, 1.77\% acid insoluble ash, 5.15\% water-soluble ash, and 8.55\% sulfated ash. Other parameters such as extractive value, foreign matter, moisture content, swelling index, foaming index, pH of different solvents, and fluorescence analysis were also determined. Both the methanolic and aqueous extracts of A. propinquum showed dose-dependent anthelminthic activity against P. posthuma compared to standard albendazole. Conclusion: This is the first report on the pharmacognostic studies and anthelminthic activity of A. propinquum Schott. Data composed from such studies can be used as a standard in the quality control of this plant used as an herbal medicine for the treatment of various diseases.

}, keywords = {Anthelminthic, Arisaema propinquum, Pharmacognostical standardization, Pheretima posthuma, Phytochemical investigation}, doi = {10.4103/pr.pr_106_19}, author = {Prince Ahad Mir and Roohi Mohi-ud-din and Mohd Akbar Dar and Ghulam Nabi Bader} }