@article {113, title = {An Open-Label, Multi-Center, Prospective, Interventional, Clinical Study to Evaluate the Efficacy and Safety of Ayuvigo Forte Capsules in Patients Suffering from Oligospermia}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {August 2019}, pages = {290-294}, type = {Original Article}, chapter = {290}, abstract = {

Background: Oligospermia refers to semen with a low concentration of sperms. Oligospermia is one of the common causative factors of male infertility. Objectives: The objective of this study was to assess the efficacy and safety of Ayuvigo forte capsule in patients suffering from oligospermia. Materials and Methods: This was an open-label, prospective, interventional, multi-center clinical study. A total of 30 patients were completed the study. All patients were advised to consume two Ayuvigo forte capsules twice daily orally after meals with a cup of milk for 90 days. Data describing quantitative measures are expressed as a mean {\textpm} standard deviation. Results: The mean total sperm count, mean progressive sperm motility, and total number of spermatozoa increased significantly (P \< 0.05) by 90.54\%, 33.65\%, and 98.88\% at the end of the study, respectively. Most patients had shown significant (P \< 0.05) improvement in subjective parameters of low sperm count assessed as per Ayurveda. Furthermore, significant (P \< 0.05) improvement was observed in mean serum free testosterone level. No statistically significant (P \> 0.05) changes were observed in mean serum luteinizing hormone, follicle-stimulating hormone, prolactin, safety laboratory parameters, and vitals. Excellent overall efficacy and tolerability were observed in majority of patients. Conclusion: Ayuvigo forte capsule is safe and effective for the management of oligospermia.

}, keywords = {Ayuvigo forte capsule, Oligospermia, Sperm count, Sperm motility, Testosterone level.}, doi = {10.4103/pr.pr_158_18}, author = {Sanjay M. Tamoli and Narendra B. Mundhe and Devdatta A. Deshmukh and Shishir Purushottam Pande and Rahul Ramkrushna Kamde and Vidyadhar S. Kumbhar and Sachin Anil Upasani and Swapnali B. Mahadik} }