@article {1165, title = {Pharmaceutico-Analytical Assessment of Jeevanthyadi ghrita-A Polyherbal Ayurveda Formulation and its Potential Benefits}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {591}, type = {Original Article}, chapter = {591}, abstract = {

Background: Standardization and documentation of Traditional medicines have caught pace in recent past and yet remain a subject of discussion. Jeevanthyadi ghrita is a commonly prescribed empirically for debilitating health conditions. However, its pharmaceutical and analytical data remains untraced. Hence an attempt was made to prepare, screen the active biological constituents and review the recent activities of ingredients of the Jeevanthyadi ghirta to rationalize the classical indications. Results: Prepared Jeevanthyadi ghrita showed presence of Alkaloids and terpenoids. HPTLC analysis detected the presence of 7 and 11 active biological constituents at 254 nm and 366 nm respectively, which remains to be identified. No significant difference was noted between plain ghrita and prepared Jeevanthyadi ghrita in relation to AGMARK parameters. Conclusion: Recent activities of ingredients showed strong anti-inflammatory and immunomodulatory effect that has a relation to ceasing the pathology of debilitation.

}, keywords = {Alkaloids, Anti-inflammatory, Debilitation, Immunomodulatory, Jeevanthyadi ghrita, Pharmaceutico-Analytical}, doi = {10.5530/pres.15.3.062}, author = {Santosh F Patil and Suhaskumar Shetty and Purnachandra T} } @article {997, title = {Seasonal Variation of Phytochemicals in Four Selected Medicinal Plants}, journal = {Pharmacognosy Research}, volume = {13}, year = {2021}, month = {October 2021}, pages = {218-226}, type = {Original Article}, chapter = {218}, abstract = {

Background: The study aimed at assessing total alkaloids content (TAC), total flavonoids content (TFC), total phenolic content (TPC), antioxidant activity (AA) and predominant individual phenolic compounds in methanol extracts of M. oleifera, S.singueana, M.azedarach leaves and stem barks of L. discolor collected during different seasons of the year. Materials and Methods: TPC, TFC and TAC were analyzed using the Folin Ciocalteau assay, aluminum chloride assay and bromocresol green assay, respectively. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) techniques were used to analyse AA. Phenolic compounds; Vanillic acid, (+)-catechin, quercetin, rutin, sinapic acid, 2,4-hydroxybenzoic acid and ferulic acid were analyzed using high performance liquid chromatography diode array detector (HPLC - DAD). Results: Barks of L. discolour exhibited high levels of TPC, TFC, TAC and AA during hot-dry season (summer) as compared to S. singueana, M. oleifera and M. azedarach leaves which showed significantly (p\< 0.05) higher levels in hot-wet season (rainy). Levels of TPC, TFC and TAC were significantly (p\< 0.05) influenced by seasonal variations and correlated with levels of AA. Profiles of all phenolic compounds analyzed were not similar in terms of chemical composition and concentration during different seasons. Sinapic acid and 2,4-hydroxybenzoic acid were predominant in S. singueana while sinapic acid and ferulic acid were predominant in M. oleifera. Vanillic acid and 2,4-hydroxybenzoic acid were predominant in L. discolor and M. azedarach respectively. Conclusion: The phytochemical constituents in medicinal plants are subject to seasonal variations which in turn influence the optimum season of harvesting.

}, keywords = {Alkaloids, Antioxidant activity, Flavonoids, Medicinal plants, Phenolic compounds, Seasonal variations}, doi = {10.5530/pres.13.4.14}, author = {Bonface Mwamatope and David Tembo and Elizabeth Kampira and Cecilia Maliwichi-Nyirenda and Victoria Ndolo} }