@article {1467, title = {Evaluation of Structural, Physical and Cytotoxicological Properties of Cissus quadrangularis, Carrageenan and Extracellular Matrix Based Guided Tissue Regeneration Membrane}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {1037-1043}, type = {Original Article}, chapter = {1037}, abstract = {

Background: Bone tissue engineering has increasingly focused on developing bioactive composite membranes from natural polymers to enhance periodontal regeneration. This study aimed to compare the structural, physical, and cytotoxic properties of a type 1 collagen-Guided Tissue Regeneration (GTR) membrane with a novel GTR membrane combining Cissus quadrangularis, carrageenan, and ovine extracellular matrix. Materials and Methods: The GTR membranes were fabricated using a CaCl$_{2}$-induced gelation process followed by freeze-drying. Group 1 included a type 1 collagen membrane (Perio Col), and Group 2 included the novel membrane. Structural and physical properties were assessed using FTIR, SEM, tensile strength, swelling, and contact angle analysis. Results: Group 2 showed superior tensile strength (28.9 MPa) compared to Group 1 (16.1 MPa), lower swelling ratios (52\% vs. 66\%), and a reduced contact angle (68{\textdegree} vs. 87{\textdegree}), indicating better wettability. The MTT assay demonstrated significantly enhanced cytocompatibility in Group 3 (cells exposed to the novel membrane with a plant compound), which exhibited 92{\textpm}4\% cell viability compared to Group 2 (85{\textpm}5\%) and the control group (100\%). Statistical analysis (p\<0.01) confirmed the novel membrane{\textquoteright}s enhanced biocompatibility due to the addition of the plant compound. Conclusion: These findings highlight the novel membrane{\textquoteright}s potential as a regenerative material for periodontal applications, with its favourable mechanical properties, improved wettability, and cytocompatibility making it a promising scaffold for tissue regeneration and therapeutic advancements in regenerative medicine.

}, keywords = {Carrageenan, Cissus quadrangularis, Extracellular matrix, Guided tissue Regeneration, Membrane, Periodontal regeneration}, doi = {10.5530/pres.20252234}, author = {Balaji Ganesh Subramanian and Uma Maheswari and Gurumoorthy Kaarthikeyan and Taniya Mary Martin and Meenakshi Sundaram Kishore Kumar} } @article {1262, title = {Phyto-Pharmacognostical Standardization of Three Morpho-Variants of Cissus quadrangularis L.}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {518-530}, type = {Original Article}, chapter = {518}, abstract = {

Background: Cissus quadrangularis is a perennial climber belonging to the Vitaceae family. The plant is characterized by its succulent stems, which are square in cross-section, hence the specific epithet "quadrangularis." It is used exhaustively in treating osteoporosis and healing bone injury/ fracture due to its rich calcium, phosphorous and phytoestrogen content. The morphological variants C. quadrangularis viz. quadrangular, flat and round stemmed varieties are reported and used for the same purpose. Objectives: The current study aims to establish a comparative assessment of the morpho-anatomical and phytochemical characteristics of C. quadrangularis stem variants, specifically the round, flat and quadrangular varieties. Materials and Methods: The present study involved a comparative macroscopic and microscopic characterization, preliminary phytochemical screening and Chromatographic evaluation (HPTLC) of the stem samples of variants of C. quadrangularis. Results: The present study revealed a lot of similarities in anatomical characteristics, physicochemical parameters, phytochemical analyses and chromatographic observations. Conclusion: Phyto-pharmacognostic standards were established for three morpho-variants of C. quadrangularis.

}, keywords = {Asthisamhara, Cissus quadrangularis, Hadjod, HPTLC., Microscopy, SEM, Stereomicroscopy}, doi = {10.5530/pres.16.3.62}, author = {Goli Penchala Pratap and Mohd. Kashif Husain and Shyam Baboo Prasad and Arun Manohar Gurav and Mokhtar Alam and Goli Penchala Prasad and Younis Iftikhar Munshi} } @article {835, title = {Lipid Constituents from Cissus quadrangularis Leaves}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {231-233}, type = {Original Article}, chapter = {231}, abstract = {

A phytochemical investigation of Cissus quadrangularis leaves yielded five additional known compounds including eicosyl eicosanoate, tetratriacontanol, tetratriacontanoic acid, α-amyrin and β-sitosterol. The characterization of isolated compounds was achieved by chemical and spectral studies (IR, 1H NMR and Mass Spectroscopy).

}, keywords = {Cissus quadrangularis, Lipids, Vitaceae}, doi = {Nil}, author = {Jain Vandana and Thakur Achal and Hingorani Lal and Laddha KS} } @article {825, title = {Phytochemical Studies on Cissus quadrangularis Linn}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {213-215}, type = {Original Article}, chapter = {213}, abstract = {

Cissus quadrangularis Linn. (Family: Vitaceae) is an ancient medicinal plant, named as Hadjod in Hindi. A triterpene δ-amyrin acetate (1), aliphatic acid hexadecanoic acid (3) and stilbene glucoside trans-resveratrol-3-O-glucoside (9) were isolated for the first time from the stems of Cissus quadrangularis, along with previously reported compounds namely, δ- amyrone (2) δ-amyrin (4), β-sitosterol (5), kaempferol (6), quercetin (7) and resveratrol (8). The structure elucidation of the isolated compounds were performed by spectroscopic techniques (IR, UV, 1H-NMR, 13C-NMR and MS) and by direct comparison with literature.

}, keywords = {Cissus quadrangularis, Delta-amyrin acetate, Hexadecanoic acid, Trans-resveratrol-3-O-glucoside}, doi = {Nil}, author = {Achal Thakur and Vandana Jain and L. Hingorani and K.S. Laddha} }