@article {853, title = {Cytotoxic Essential Oil from Annona sengalensis Pers. Leaves}, journal = {Pharmacognosy Research}, volume = {2}, year = {2021}, month = {September 2010}, pages = {211-214}, type = {Original Article}, chapter = {211}, abstract = {

The cytotoxicity against brine shrimp of the essential oil obtained from the leaves of Annona senegalensis Pers. (Annonaceae) was studied. The confirmation of this toxicity has been done by using selected tumor cell lines (A549, HT29, MCF 7, RPMI, and U251). The results showed that the total oil and its fractions have showed mild to moderate cytotoxicity in brine shrimp lethality bioassay with LC50 = 27.3 μg/ml, and against some human tumor cell lines. The total oil and its fractions were analyzed by gas chromatography/mass spectroscopy (GC/MS). Seventy three compounds were identified.

}, keywords = {Annona senegalensis, Brine shrimp, cytotoxicity, Essential oil, GC/MS}, doi = {10.4103/0974-8490.69105}, author = {A L Ahmed, and S E M Bassemx and Y H Mohamed and MW Gamila} } @article {855, title = {Brine shrimp Lethality and Acute Oral Toxicity Studies on Swietenia mahagoni (Linn.) Jacq. seed Methanolic Extract}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {September 2010}, pages = {215-220}, type = {Original Article}, chapter = {215}, abstract = {

Background: The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract. Methods: SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice. Results: The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg. Conclusion: This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

}, keywords = {Acute oral toxicity, Brine shrimp, Swietenia mahagoni seeds}, doi = {10.4103/0974-8490.69107}, author = {Geethaa Sahgal and Surash Ramanathan and Sreenivasan Sasidharan and Mohd Nizam Mordi and Sabariah Ismail and Sharif Mahsufi Mansor} } @article {773, title = {Cytotoxic Acetogenins from Annona glabra Cultivated in Egypt}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {130-135}, type = {Original Article}, chapter = {130}, abstract = {

Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.

}, keywords = {Acetogenin, Annona glabra, Annonaceae, Brine shrimp, Cytotoxic}, doi = {Nil}, author = {Ahmed Abdel-Lateff and Bassem S. El-Menshawi and Mohamed Y. Haggag and Mahmoud A. Nawwar} }