@article {1315, title = {Melezitose a Potential of Bioactive Compound from Aqueous Extract of Indian Satavari: An Web Based in silico Study Utilizing GC-MS Analysis}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {887-896}, type = {Original Article}, chapter = {887}, abstract = {

Background: Historical records indicate that medicinal plants and their components have been utilized for treating diverse conditions since antiquity. Asparagus racemosus, in particular, demonstrates a broad spectrum of therapeutic possibilities. Aim: This study aimed to pinpoint potential bioactive compounds found within the aqueous extract of Asparagus racemosus. Materials and Methods: Gas Chromatography employed to identify the presence of various molecules, while Mass Spectrometry and FTIR analysis validated their molecular structures. The molecule was subjected to thorough scrutiny for its potential as a drug candidate, its biological activity, and its predicted targets using in silico techniques. Results: The aqueous extract stands out as the richest reservoir of carbohydrates and steroidal alkaloids. The molecule Melezitose was found in the highest concentration (37.86\%). The identified molecule is a carbohydrate in nature. The computational analysis revealed promising drug-like properties and therapeutic potential for the investigated molecule. Conclusion: It could serve as a viable therapeutic option for addressing multiple disorders.

}, keywords = {Aqueous extract, Asparagus racemosus, Chromatography, In silico study, Mass spectroscopy, Target analysis}, doi = {10.5530/pres.16.4.101}, author = {Sandip Sen and Kalepu Swathi and Dubbasi Vishwanath and Bairam Ravindar and Mitta Chaitanya and Srinivas Cherukupally and Shapuram Tejasree and Hema Varaha Santhoshi Allu} } @article {878, title = {Antidiabetic Activity and Phytochemical Screening of Crude extract of Stevia rebaudiana in Alloxan-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {September 2010}, pages = {258-263}, type = {Original Article}, chapter = {258}, abstract = {

Background: Stevia rebaudiana regulates blood sugar, prevents hypertension and tooth decay. Other studies have shown that it has antibacterial as well as antiviral property. Methods: Preliminary phytochemical screening of aqueous, ether and methanolic extracts of S. rebaudiana was done. Acute and sub-acute toxicity were conducted on twenty four Albino rats, divided into one control (Group I) and three treatment groups viz. aqueous extract (Group II), ether extract (Group III) and methanolic extract (Group IV). For the study of antidiabetic effect of S. rebaudiana rats were divided into seven groups (n=6). Diabetes was induced by a single dose of 5\% alloxan monohydrate (125 mg/kg, i.p.) after 24 hour fasting.Blood samples were analysed on day 0, 1, 5, 7, 14 and 28. Results: Phytochemical tests showed presence of different kinds of phyto-constituents in aqueous, ether and methanol extract of Stevia rebaudiana leaves. Daily single dose (2.0 g/kg) administration of aqueous extract (A.E.) , ether extract (E.E.) and methanol extract (M.E.) for 28 days of S. rebaudiana could not show any significant change in ALT and AST levels in rats. Blood sugar level was found to be decreased on day 28 in groups of rats treated with A.E., E.E. and M.E. of S. rebaudiana. Conclusion: The extracts of Stevioside rebaudiana could decrease the blood glucose level in diabetic rats in time dependent manner.

}, keywords = {Aqueous extract, Diabetes, Ether extract, Methanol extract, Rats, Stevia rebaudiana, Sub-acute toxicity}, doi = {10.4103/0974-8490.69128}, author = {R. S. Kujur, Vishakha Singh and Mahendra Ram and Harlokesh Narayan Yadava and K K Singh and Suruchi Kumari and B. K. Roy} } @article {951, title = {Anti-inflammatory Activity of Aqueous extract of Mirabilis jalapa Linn. Leaves}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {January 2011}, pages = {364-367}, type = {Original Article}, chapter = {364}, abstract = {

Background: The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods: Aqueous extract of the leaves was prepared by cold maceration. Results: The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P \< 0.05) inhibition of paw oedema, 37.5\% and 54.0\% on 4 th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9\% and 43.0\% on 4 th day at the doses of 200 and 400 mg/kg, respectively. Conclusion: The results of present study demonstrate that aqueous extract of the leaves possess significant (P \< 0.05) anti-inflammatory potential.

}, keywords = {anti-inflammatory activity, Aqueous extract, Mirabilis jalapa, Paw edema}, doi = {10.4103/0974-8490.75456}, author = {Manjit Singh and Vijender Kumar and Ishpinder Singh and Vinod Gauttam and Ajudhia Nath Kalia} } @article {765, title = {Antiulcer Activity of Aqueous extract of Fruits of Momordica Cymbalaria Hook f. in Wistar Rats}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {March 2010}, pages = {58-61}, type = {Original Article}, chapter = {58}, abstract = {

Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5\%-10\% of people during their life. The ulcer is an open sore that develops on the inside lining of the stomach (a gastric ulcer) or the small intestine (a duodenal ulcer). Both types of ulcers are also referred to as peptic ulcer disease. The present study was carried out to investigate antiulcer activity of aqueous extract of fruits of Momordica cymbalaria Hook f. Initially the aqueous extract of M. cymbalaria was subjected to acute oral toxicity study according to the Organisation for Economic Co-operation and Development (OECD) guidelines, based on which, 500 mg/kg dose of aqueous extract was selected for the study. The animals were pretreated before inducing ulcer. For inducing ulcer in the rats, 80\% ethanol was used. Various parameters such as area of gastric lesion, nonprotein sulfhydryls (NP-SH) concentration, gastric wall mucus concentration, total acidity and volume of gastric content; and histopathological parameters like hemorrhage, edema, erosion, ulceration were studied in the control group and pretreated groups with aqueous extract of fruits of Momordica cymbalaria (500 mg/kg) and standard drug lanzoprazole (30 mg/kg). Pretreatment with aqueous extract of M. cymbalaria fruits showed significant ( P \< 0.05) decrease in the total acidity and ulcer index. Improvements in all histopathological parameters were noticed in the M. cymbalaria-treated group. It also showed significant decrease in gastric lesion and NP-SH and gastric wall mucus concentrations in the M. cymbalaria-treated group. Overall the aqueous extract of M. cymbalaria fruits was shown to possess significant ( P \< 0.05) antiulcer property in rats. The polyphenols like quercetin reported from the plant may attribute to the antiulcer property of the extract.

}, keywords = {Antiulcer activity, Aqueous extract, Gastric ulcer, Momordica cymbalaria, Momordica tuberosa}, doi = {10.4103/0974-8490.60575}, author = {P Bharathi Dhasan and M Jegadeesan and S Kavimani} }