@article {1072, title = {Anti-inflammatory Potential of Euphorbia helioscopia Extracts against RAW264.7 Macrophages}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {July 2022}, pages = {338-341}, type = {Original Article}, chapter = {338}, abstract = {

Background: Euphorbia helioscopia, commonly known as sun spurge, is one of the largest species of an annual herb in the family Euphorbiaceae, which is extensively distributed worldwide. In folk medicine, it is used to treat various ailments such as malaria, osteomyelitis, and gastrointestinal ailments. The anti-inflammatory potential of Euphorbia helioscopia extracts on LPS-stimulated RAW264.7 macrophages was investigated in this work. Results: The ethanol extract was found to markedly inhibit the pro-inflammatory cytokines (IL-6 and TNFα) production compared to the aqueous extract treated cells. Moreover, extracts downregulated the nitric oxide levels. Finally, in this study, we have shown that Euphorbia helioscopia exerts a potent pharmacological effect on reducing the inflammatory response in macrophages. Conclusion: The results of the experiment revealed that the Euphorbia helioscopia extracts used in this study have anti-inflammatory characteristics, with the ethanolic extract having the most. The ethanolic extract had the strongest anti-inflammatory impact in terms of greatest reduction of proinflammatory indicators including IL-6, TNF-, and NO.

}, keywords = {Anti-inflammatory, ELISA, Euphorbia helioscopia, IL-6, TNF-α}, doi = {10.5530/pres.14.3.50}, author = {Iram Jan and Nusrit Iqbal Andrabi and Yassir Arfath and Tazeem Akram and Tusharika Kotra and Zabeer Ahmed and Mithilesh Kumar} } @article {745, title = {The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {April 2011}, pages = {30-34}, type = {Original Article}, chapter = {30}, abstract = {

Background:\ Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant\ Ficus religiosa\ on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats.\ Methods:\ Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of\ F. religiosa\ at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed.\ Results:\ Aqueous extract of\ F. religiosa\ at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect.\ Conclusion:\ Modulation of cytokine TNF-α by the aqueous extract of\ F. religiosa\ indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.

}, keywords = {Ficus religiosa, Inflammation, TNF-α, type 2 diabetes}, doi = {10.4103/0974-8490.79112}, author = {H Kirana and MV Jali and BP Srinivasan} }