@article {774, title = {Exploiting the Phenomenal Anti-ulcerogenic Potential of Talinum portulacifolium Ethanolic Extract Whole Plant on Albino Rats: The Therapeutic Potential of Chinese Herb-mǎ chǐ xi{\`a}n ke (Portulacaceae)}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {May,2014}, pages = {227-233}, type = {Original Article}, chapter = {227}, abstract = {

Background: Ulcerations have been effecting humans and causing major damage in the gastro intestinal tract. A need for development of a flawless anti-ulcer medication was always in the agenda. Thus, the need to conduct a study was provoked. Objectives: The major objective of the present study is to screen the antiulcer activity of the ethanolic extract of Talinum portulacifolium (Forsk) plant. Materials and Methods: The antiulcer activity of the ethanolic extract of T.Z portulacifolium was performed on albino rats. Gastric ulcers were induced by ethanol, pylorus ligated aspirin and histamine induced ulcer models. Omeprazole was used as a standard drug for comparison. Results: Treatment with the T. portulacifolium plant extract significantly protected the ulceration induced by the three models. The gastric volume, pH of gastric juice, total acidity, free acidity and ulcer index were the parameters estimated and did show significant results. 800 mg/kg extracts of T. portulacifolium did show high significant results as that of standard drug. Percentage protection of 800 mg/kg was 79.9\% and the standard drug-treated group did show 84\%. So was with total acidity (38.1 + 1.45) and free acidity (16.5 + 0.76) Conclusion: The ethanolic extract of T. portulacifolium plant was found to possess a significant antiulcer activity.

}, keywords = {ethanol, Histamine, Omeprazole, Pylorus-ligated aspirin, Talinum portulacifolium}, doi = {10.4103/0974-8490.132600}, author = {Rohit Gundamaraju and Kotla Maheedhar and Kim Kah Hwi} } @article {736, title = {Solanum Trilobatum in the Management of Atopy: Through Inhibition of Mast Cell Degranulation and Moderation of Release of Interleukins}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {March 2010}, pages = {10-14}, type = {Original Article}, chapter = {10}, abstract = {

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

}, keywords = {Histamine, Immunomodulation, Interleukin, Mast cell, Medicinal plants, Solanum trilobatum}, doi = {10.4103/0974-8490.60581}, author = {MS Ranjith and A J A Ranjitsingh and S Gokul Shankar and GS Vijayalaksmi and K Deepa and K Babu and Harcharan Singh Sidhu} }