@article {1224, title = {Hyperlipidemic Potential of Polyherbal Siddha Formulation D5 Chooranam}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {376-383}, type = {Original Article}, chapter = {376}, abstract = {

Background: Hyperlipidemia is an important public health problem with increasing incidence and prevalence worldwide. D5 Chooranam is a synergetic Siddha polyherbal formulation designed by Central Council for Research in Siddha which is under patent process. Materials and Methods: In this study assessment of antihyperlipidemic activity of D5 Chooranam was carried out using high fat diet-induced hyperlipidemic model. After 8 weeks of induction hyperlipidemia, the male Wistar rats were treated orally with 250 mg/kg, 500 mg/kg and 750 mg/kg of D5 Chooranam for 6 weeks. Results: The results demonstrated significant hypolipidemic activity by lowering total cholesterol, Low Density Lipoprotein (LDL), Very Low-Density Lipoprotein (VLDL), and triglycerides and by increasing HDL levels compared to hyperlipidemic rats. Atorvastatin (10 mg/kg) was used as a positive control. The reduced AST and ALT levels showed its protective role against hepatic damage. Histopathological findings in rat liver supported the protective role of D5 Chooranam in HFD-induced fatty liver. No significant changes in the renal and cardiac markers provide evidence that D5 Chooranam may not possess serious side effects. Conclusion: Therefore, the study suggests that D5 Chooranam could be effective in treating hyperlipidemia.

}, keywords = {cholesterol, HDL, High fat diet, Hyperlipidemia, Low density lipoprotein, Siddha formulation.}, doi = {10.5530/pres.16.2.47}, author = {Gaddam Dayanand Reddy and Rethinam Ganesan and Manikantavinay Jayavaram and Venkata Narasimhakumar G and Bhavani Krishnamoorthy and Shahana Ahamed} } @article {699, title = {Effect of Coleus Forskohliiextract on Cafeteria Diet-induced Obesity in Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {December,2013}, pages = { 42-45}, type = {Original Article}, chapter = { 42}, abstract = {

Background: Obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. This study was designed to determine the effect of Coleus forskohlii on obesity and associated metabolic changes in rats fed with cafeteria diet. Objective: The aim of this study was to evaluate antiobesogenic and metabolic benefits of C. forskohlii in cafeteria diet induced obesity rat model. Materials and Methods: Rats were randomly divided into five groups of six animals in each group and as follows: Normal pellet diet group; cafeteria diet group; cafeteria diet followed by 50 mg/kg/d Coleus forskohlii extract (CFE), 100 mg/kg/d CFE and 45 mg/kg/d orlistat groups, respectively. Indicators of obesity such as food intake, body weight and alteration in serum lipid profiles were studied. Results: Feeding of cafeteria diet induced obesity in rats. Administration of CFE significantly halted increase in food intake and weight gain associated with cafeteria diet. Development of dyslipidemia was also significantly inhibited. Conclusion: The observed effects validate that supplementation of CFE with cafeteria diet could curb the appetite and mitigate the development of dyslipidemia.

}, keywords = {Appetite, Cafeteria diet, cholesterol, Coleus forskohlii, Lipid profile}, doi = {10.4103/0974-8490.122916}, author = {Hebbani Nagarajappa Shivaprasad and Sushma Gopalakrishna and Bhanumathy Mariyanna and Midhun Thekkoot and Roopa Reddy and Boreddy Shivanandappa Tippeswamy} } @article {931, title = {Benincasa cerifera Ameliorates Renal Ischemia/Reperfusion Injury in Hyperlipidemic Rat}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {406-409}, type = {Original Article}, chapter = {406}, abstract = {

To investigate protective effect of Benincasa cerifera (BC) against kidney injury induced by Ischemia/Reperfusion (I/R) in hyperlipidemic (HC) rats. Hyperlipidemia was developed by cholesterol diet (2\% cholesterol and 20 \% coconut oil) feeding for 3 weeks. At the end of 3rd week, renal ischemia was induced by both renal arteries occlusion for 60 min followed 24 h of reperfusion. Methanolic extract of Benincasa cerifera (500 mg/kg/day) was administered orally 7 days before induction of ischemia. Benincasa cerifera treatment reversed all antioxidant parameters like superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) contents as well serum creatinine and blood urea nitrogen (BUN) levels. This data conclude the renoprotective activity of Benincasa cerifera against renal damage induced by ischemia/reperfusion injury in hyperlipidemic rat.

}, keywords = {Benincasa cerifera, cholesterol, Oxidative stress, Renal ischemia/reperfusion injury}, doi = {Nil}, author = {Bhalodia Y.S and Patel N.J and Patel R.K and Vaghasiya J.D and Jivani N.P and Sheth N.R} }