@article {1190, title = {Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {813-818}, type = {Original Article}, chapter = {813}, abstract = {

Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p\<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p\<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p\<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future.

}, keywords = {Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensis}, doi = {10.5530/pres.15.4.086}, author = {Thopireddy Lavanya and Kakarla Chandra Mohan and Kesireddy Sathyavelu Reddy and Saddala Rajeswara Reddy} } @article {94, title = {Phytochemical Content and Antioxidant Activities of Pomelo Peel Extract}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {August 2019}, pages = {244-247}, type = {Original Article}, chapter = {244}, abstract = {

Background: There is an increasing interest in the antioxidant measurement of some plant constituents. Plant component, especially fruit, has antioxidant components which are safe, economic, and powerful to reduce oxidative stress and replace synthetic ones. Objectives: To quantitatively measure the flavonoids, Vitamin C, and carotenoid content of hydroalcoholic extract and to estimate the antioxidant activity of pomelo peel extract (PPE) and minimum inhibitory concentration 50\% (IC50) of the extract using 2,2-diphenyl-1-picrylhydrazyl (DPPH) ethanolic solution. Materials and Methods: Hydroalcoholic PPE was prepared; total flavonoids using aluminum chloride method, Vitamin C using thiourea and 2,4-dinitrophenylhydrazine method, and carotenoid content of the extract were estimated using 95\% ethanol solution. All measurements were estimated using ultraviolet{\textendash}visible spectrophotometer. Antioxidant activity and IC50 of PPE were measured using DPPH method. Results: Flavonoids, Vitamin C, and carotenoid content were measured as 21.20 mg/100 g, 15.13 mg/100 g, and 62.98 μg/g, respectively, of dry PPE. The DPPH radical scavenging activity exhibits a significant dose-dependent inhibition of DPPH radical color, with IC50 being at a concentration of 68.55 μg/ml of the extract, comparable to 55.87 μg/ml IC50 of Vitamin C standard antioxidant. Conclusion: From the study results, we could conclude that pomelo peel possesses high antioxidant properties and it is potentially rich sources of natural antioxidants.

}, keywords = {2, 2-diphenyl-1-picrylhydrazyl, Antioxidant capacity, Ascorbic acid, Citrus maxima., Flavonoids}, doi = {10.4103/pr.pr_180_18}, author = {Zead Helmi Abudayeh and Ihab Ibrahim Al Khalifa and Shaimaa M. Mohammed and Asser Ashraf Ahmad} }