@article {802, title = {Antihyperlipidemic Potential of Albizia amara (Roxb) Boiv. Bark Against Triton X-100 Induced Hyperlipidemic Condition in Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, abstract = {

Background: The plant Albizia amara (Roxb.) Boiv. bark was used in traditional medical practices of India to treat cardiovascular diseases. Hyperlipidemia is the greatest risk factor of coronary heart disease. Objective: The objective of this study was to screen the potential of A. amara against the condition of hyperlipidemia in rats. Materials and Methods: The antihyperlipidemic activity of A. amara ethanolic extract (AAEE) was studied on Triton X-100 induced model of hyperlipidemia in rats. Hyperlipidemia in experimental rats was evidenced by an enhancement in the levels of serum cholesterol, triglycerides (TGs), low density lipoprotein (LDL), very LDL (VLDL) and decrease in high density lipoprotein (HDL). Results: AAEE showed significant antihyperlipidemic effect by lowering the serum levels of biochemical parameters such as a significant reduction in the level of serum cholesterol, TG (104.1 {\textpm} 3.39), LDL (48.2 {\textpm} 2.19), VLDL (20.81 {\textpm} 0.67) and increase in HDL (47.25 {\textpm} 2.05) level with an increase in a dose of AAEE (41.39 {\textpm} 1.24) \< (47.25 {\textpm} 2.05), which was similar to the standard drug atorvastatin. The results of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase also revealed that the plant extract was found to be safe on liver. Histopathological evaluation also revealed the positive effect of the plant extract. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as saponins, glycosides and tannins. The preliminary chemical constituents stood as a strong evidence for the study. Conclusion: Summing up the evidences of the pragmatic study, we can conclude that the extract of A. amara (Roxb.) Boiv. Bark aids in declining the condition of hyperlipidemia in rats.

}, keywords = {Albizia amara, Atorvastatin, Hyperlipidemia, Triton X-100}, doi = {10.4103/0974-8490.138237}, author = {Rohit Gundamaraju and Kim Kah Hwi and Rajeev K Singla and Ravi Chandra Vemuri and Sartaj Banu Mulapalli} } @article {650, title = {Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats)}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = { 157-161}, type = {Original Article }, chapter = {157}, abstract = {

Background:\ Diabetic mellitus and hypothyroidism lead to serum lipoproteins disorders. This study aims to investigate the potential effect of fresh ginger extracts\ Zingiber officinale\ roscoe (Family:\ Zingebiraceae) on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. Rats were divided into 11 groups: The normal G1, diabetic control rats G2, ginger 500 mg/kg treated diabetic rats G3, 10 mg/day atorvastatine-treated diabetic rats G4, [5 mg/day atorvastatine combined with 500 mg/kg ginger] treated diabetic rats G5, glibenclamid-treated diabetic rats G6, hypothyoidism control rats G7, 300 mg/kg ginger-treated hypothyroidism rats G8, 500 mg/kg ginger-treated hypothyroidism rats G9, 10 mg/day atorvastatine-treated hypothyroidism rats G10, [atorvastatine combined with 500 mg/kg ginger]treated hypothyroidism rats G11. Thirty days after treatment, samples were collected, to compare treated groups with normal and control groups, using Mann-Whitney U test\ P\ \< 0.01.\ Results\ : It revealed a decrease in the levels of total cholesterol (TC), and low density lipoprotein (LDL) in the serum of rats that were treated by ginger extracts, compared with the control groups. Previous extracts were also able to cause reduction in LDL to similar levels compared to normal group and that was the same effect of atorvastatin 10 mg/day. Combined effect was clear between the act of ginger at a dose of 500 mg/kg and atorvastatin; that levels of both TC and LDL in animals which received [atorvastatin 5 mg/day combined with ginger extract] was almost equal to levels in animals that received atorvastatin 10mg/day. Clear reduce in triglyceride, and clear increase in high density liopprotein were also recorded in the ginger-treated groups. Ginger was more active in hypothyroidism rats than in diabetic rats in reducing LDL and TC. Glucose levels were substantially reduced in ginger- treated diabetic groups.

}, keywords = {Alloxan-induced Diabetes, Atorvastatin, Ginger, Glibenclamide, Lipoproteins}, doi = {10.4103/0974-8490.112419 }, author = {Ahmad Sameer Al-Noory and Abdul-Nasser Amreen and Shatha Hymoor} }