@article {633, title = {Anti-arthritic Activity of Ethanolic Extract of Tridax Procumbens (Linn.) in Sprague Dawley Rats}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = { 113-117}, type = {Original Article }, chapter = {113}, abstract = {

Objective:\ To determine the anti-arthritic effect of whole plant ethanolic extract of\ Tridax procumbens\ (Asteraceae) in female Sprague Dawley (SD) rats using the Freund{\textquoteright}s Complete Adjuvant (FCA) model.\ Materials and Methods:\ The plant was collected from different regions of Madurai District, Tamil Nadu, and the phytoconstituents were identified through chemical tests. Ethanol (95\%) was used to obtain the whole plant extraction through Soxhlet extractor. Female SD rats were used for anti-arthritic screening. Arthritis was induced using FCA, and the anti-arthritic effect of the ethanolic extract of\ T. procumbens\ was studied at doses of 250 and 500 mg/kg. The effects were compared with those of indomethacin (10 mg/kg). At the end of the study, the liver enzyme levels were determined and a radiological examination was carried out.\ Result:\ The preliminary phytochemical analysis of the ethanolic extract of\ T. procumbens\ indicated the presence of alkaloids, tannins, flavonoids and saponins.\ T. procumbens\ at 250 and 500 mg/kg significantly inhibited the FCA-induced arthritis in the rats. This was manifested by as a decrease in the paw volume. The arthritic control animals exhibited a significant decrease in body weight compared with control animals without arthritis.\ T. procumbens\ animals showed dose dependent reduction in decrees in body weight and arthritis. At the same time,\ T. procumbens\ significantly altered the biochemical and haematological changes induced by FCA (\ P\ \< 0.05). The anti-arthritic effect of\ T. procumbens\ was comparable with that of indomethacin.\ Conclusion:\ The whole plant extract of\ T. procumbens\ showed significant anti-arthritic activity against FCA-induced arthritis in female SD rats.

}, keywords = {Arthritis, Freund's Complete Adjuvant, T. Procumbens}, doi = { 10.4103/0974-8490.110541}, author = {R Ramesh Petchi and C Vijaya and S Parasuraman} } @article {637, title = {Anti-arthritic Activity of Root Bark of Oroxylum Indicum (L.) Vent Against Adjuvant-induced Arthritis}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = {121-128}, type = {Original Article }, chapter = {121}, abstract = {

Background:Oroxylum indicum\ (Bignoniaceae) also known as Sonapatha is an indigenous medicinal plant widely used in Ayurvedic medicine for over thousands of years. It is an active ingredient of well-known Ayurvedic formulations such as Chyawanprash and Dasamula. Root bark of this plant has tonic and astringent properties and it is also used in rheumatism.\ Objective:\ The present investigation was carried out to evaluate the anti-arthritic activity of different extracts of root bark of\ Oroxylum indicum\ against adjuvant - induced arthritis in rats.\ Materials and Methods:\ Male Wistar rats were used in this study. Arthritis was induced by injecting 0.1 ml Freund{\textquoteright}s complete adjuvant intra-dermally into the left hind paw of the rats. The paw volume, hematological, biochemical, radiographic and histopathological aspects were evaluated.\ Results:\ The relative percentage inhibition potential of paw volume in rats treated with various extracts of\ Oroxylum indicum\ was found to be ethyl acetate extract (67.69\%) \>chloroform extract (64.61\%) \>n-butanol extract (58.46\%) respectively. The hematological parameters like RBC count, hemoglobin content showed significant increase while there was a significant decrease in total WBC count and ESR in all the groups of animals pretreated with root bark extracts. The biochemical parameters such as catalase, glutathione contents showed a significant increase while the lipid peroxide and Cathepsin-D content decreased significantly only in case of ethyl acetate pretreated rats when compared to others.\ Conclusion:\ The present study suggests that the chloroform, ethyl acetate and n-butanol extracts of root bark of\ Oroxylum indicum\ exhibit anti-arthritic activity. The order of activity of extracts was found to be ethyl acetate \>chloroform \>n-butanol respectively.

}, keywords = {Anti-arthritic Activity, Biochemical parameters, Freund's Complete Adjuvant, Histopathology, Oroxylum indicum}, doi = { 10.4103/0974-8490.110543}, author = {Mamatha Karnati and Rodda H Chandra and Ciddi Veeresham and Bookya Kishan} }