@article {1226, title = {Detection of HPTLC Fingerprint in Aerial Parts of Aerva lanata Linn. HPTLC Finger Print Profile and Evaluation of in vitro Antioxidant Activity of Aerva lanata Linn. Juss}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {236-243}, type = {Original Article}, chapter = {236}, abstract = {

Background: Natural products enhance the standard of living, which greatly contributes to maintaining human health. Associated oxidative stress-mediated problems have been treated using Aerva lanata Linn. Juss in traditional and folkloric medicine. Objectives: The research aims to analyze the phytochemical profile using HPTLC of MEAL (methanol extracts of Aerva lanata) and AEAL (aqueous extracts of Aerva lanata) and to determine in vitro antioxidant capacity of MEAL and AEAL. The use of HPTLC fingerprint analysis will aid in identifying and monitoring drug effectiveness and ensuring therapeutic efficacy. Materials and Methods: Total phenol content, free radical scavenging efficiency of DPPH (1,1 diphenyl 2 picryl hydrazyl), ferric ion reducing antioxidant, and phosphomolybdate assays were used to determine in vitro antioxidant activity at various concentrations. Results: The number of phyto-constituents in MEAL at 375 nm and 550 nm was found to be more than AEAL. MEAL had a, stronger DPPH free radical scavenging capacity, higher phenol content, lower ferric ion antioxidant potential, and lower phosphomolybdenum assay. The natural phytoconstituents present in the plant extracts are responsible for antioxidant activity. As sample concentration increases, the antioxidant activity becomes more effective. Conclusion: The outcome results of the present investigation suggested that aerial parts ofAerva lanata could provide a source of natural antioxidants.

}, keywords = {Aerva lanata, DPPH, Fingerprint profile, HPTLC, in vitro antioxidant activity., Physicochemical parameters}, doi = {10.5530/pres.16.2.30}, author = {Rajesh. R} } @article {629, title = {Aerva Ianata (Polpala): Its Effects on the Structure and Function of the Urinary Tract}, journal = {Pharmacognosy Research}, volume = {4}, year = {2012}, month = {October ,2012}, pages = {181-188}, type = {Original Article}, chapter = {181}, abstract = {

Context: Aerva lanata is not prescribed for long-term use in Ayurveda as it is believed to produce structural changes in the urinary tract of the patients leading to renal failure. Aim: To investigate the toxic effects of Aerva lanata on the structure and function of urinary tract of a rat model (Sprague-Dawley rats). Settings and Design: An experimental study. Thirty male and thirty female healthy rats were randomly assigned to three groups (test groups 1, 2 and control) and administered dried infusion of A. lanata 25g/200ml (low dose), 100g/200ml (high dose) and distilled water respectively, for 30 days. Materials and Methods: Blood and urine were collected and creatinine was measured. Creatinine clearance (Ccr) and urine flow rate (UFR) of rats were determined to assess renal function. Kidneys, ureters, and bladders of rats were harvested for light microscopic (LM) studies. Electron microscopic (EM) studies were done on kidney tissues. Statistical Analysis Used: Difference in mean values of Ccr and UFR between test groups and the control group were compared statistically using independent T test. LM and EM findings of the two treated groups (T1 and T2) were statistically compared with the control group (C) using standard normal distribution. Results: Ccr and UFR of test groups were not significantly different from that of the control group. LM studies did not show any histological changes suggesting toxicity. EM, however showed significant ultra structural changes in proximal convoluted tubular epithelial cells of rats in the two test groups. Conclusion: Administration of dried Aerva lanata for a period of one month did not produce significant effects on renal function of rats. However administration for the same period caused significant ultra structural changes in the proximal convoluted tubular epithelial cells.

}, keywords = {Aerva lanata, Kidney, Sprague-Dawley rats, Toxic effects}, doi = {10.4103/0974-8490.102259}, author = {Mangala Gunatilake and M.D.S. Lokuhetty and Nuwan A Bartholameuz} }