@article {733, title = {Bioactivity of Syzygium Jambos Methanolic Extracts: Antibacterial Activity and Toxicity}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {March 2010}, pages = {4-9}, type = {Original Article}, chapter = {4}, abstract = {

Methanol extracts from S. jambos leaves were tested for antimicrobial activity and toxicity. S. jambos leaf extract inhibited the growth of 4 of the 14 bacteria tested (29\%). Both gram-positive and gram-negative bacterial growths were inhibited by S. jambos leaf extract, although gram-positive bacteria appeared more susceptible. Two of the 10 gram-negative bacteria (20\%) and 2 of the 4 gram-positive bacteria (50\%) tested had their growths inhibited by the extract. The leaf extract also proved to be toxic in the Artemia franciscana bioassay, with a 48-h LC 50 of 387.9 {\textpm} 38.8 {\textmu}g/mL, making it slightly more toxic than Mevinphos (505.3{\textpm} 37.7 {\textmu}g/mL) and approximately 5-fold less toxic than potassium dichromate (80.4 {\textpm} 4.3 {\textmu}g/mL). Whilst potassium dichromate{\textquoteright}s LC 50 remained constant across the 72-hour test period (24-h LC 50 , 86.3 {\textpm} 5.1; 72-h LC 50 , 77.9 {\textpm} 4.9), the extract and Mevinphos LC 50 values decreased by 72 hours (87.0 {\textpm} 11.3 {\textmu}g/mL and 103.9 {\textpm} 12.8 {\textmu}g/mL, respectively), indicating their similar levels of toxicity in the assay.

}, keywords = {Antibacterial, Medicinal plants, Methanolic extracts, Phytotoxicity, Rose apple, Syzygium jambos}, doi = {10.4103/0974-8490.60577}, author = {S Mohanty and IE Cock} } @article {586, title = {Preliminary Studies on Lipoxygenase Inhibitory Activity of Selected Malaysian Medicinal Plants}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {1-3}, type = {Original Article}, chapter = {1}, abstract = {

A potential source for new lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. As part of screening programme for biologically active plants, 20 extracts of different parts of 10 Malaysian medicinal plants belonging to four families were evaluated for their inhibitory activity on soybean 15-lipoxygenase (15-sLo). The leaves of Peronema canescens Jack. (Verbenaceae) were shown to be the most potent inhibitor with an IC50 value of 25.64 ,g/ml. While the extracts of P. canescens stem and Stereospermum fibricatum DC. (Bignonaceae) leaves were found to possess profound inhibitory activity with IC50 values of 33.65 and 39.41 ,g/ml, respectively. The methanol extracts obtained from Stenolobium stans (L.) D. Don (Bignonaceae) leaves and stems, Piper ribesioides Wall. (Piperaceae) stems and S. fibricatum stems were moderately active with IC50 values ranging from 40 to 60 ,g/ml. While the remaining samples showed low lipoxygenase inhibitory activity at concentration of 100 ,g/ml.

}, keywords = {15-lipoxygenase inhibitory activity, Malaysian medicinal plants, Methanolic extracts}, author = {M.P. Mazura and S.K. Ling} }