@article {1108, title = {Relative Influence of Ageratum conyzoides L. Plant Extracts on Testosterone Induced Benign Prostatic Hyperplasia in Mice}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {75-83}, type = {Original Article}, chapter = {75}, abstract = {

Purpose: The present study was designed to investigate the inhibitory efficacy of aqueous and ethanolic extracts of Ageratum conyzoide L. (AC, Family asteraceae) on testosterone induced BPH in male mice. Materials and Methods: Mice were randomly divided into five groups (n=6): negative control group received corn oil, BPH model group receive testosterone (5mg/kg/day, S.C) dissolved in corn oil. Another group received standard BPH drug finasteride (5 mg/Kg/day, I.P) along with testosterone injection (5mg/kg/day, S.C). The other two group of animals received either aqueous or ethanolic AC plant extracts (100, 500. 1000 and 2000 mg/kg, I.P) along with testosterone (5mg/kg/day, S.C) consecutively for 28 days. All animals were sacrificed at the end of the study period and prostate weight and prostatic index were determined, followed by histolopathological examination of the prostate gland. Results: The result of the present study indicated that treatment with either plant extracts caused significant reduction in prostate weight and prostatic index when compared to only testosterone treated animal group. The percentage of inhibition of prostate growth was found to be correlated in a dose dependent manner in plant extract treated groups. Histopathological examination of prostate gland revealed AC plant extracts treatment significantly reduced the glandular hyperplasia, epithelial thickness and stromal hyperplasia in the prostate gland of the treated animals. No significant elevation in serum ALT and creatinine level was recorded in any groups during the study period. Conclusion: This study hence indicate the therapeutic potential in Ageratum conyzoides L. plant extract in testosterone induced BPH model in mice.

}, keywords = {Ageratum conyzoides, Benign prostatic hyperplasia, Inhibition, Plant extracts, Prostate, Testosterone}, doi = {10.5530/097484900266}, author = {Tongchen Jomba and Manuj Kumar Bharali} } @article {475, title = {Acute Sodium Arsenite-Induced Hematological and Biochemical Changes in Wistar Rats: Protective Effects of Ethanol Extract of Ageratum conyzoides}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {March 2016}, pages = {26-30}, type = {Original Article}, chapter = {26}, abstract = {

Background: Ageratum conyzoides L. (Asteraceae) is an annual herbaceous plant used in folklore medicine for the treatment of a wide range of diseases. Objective: To investigate the protective effect of the ethanol leaf extract of A. conyzoides (EEAC) against hematological, serum biochemical and histological alterations induced by Sodium arsenite administration to Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly assigned into four groups of five rats each. Group I received propylene glycol and Group II rats were given the (EEAC, 100 mg/kg b.w.) orally for 7 days. Group III were given a single oral dose of sodium arsenite (NaAsO2, 2.5 mg/kg b.w.). Animals in Group IV were pretreated with 100 mg/kg EEAC for 7 days followed by a single oral dose of sodium arsenite. Results: Arsenic exposure resulted in significant reductions (P \< 0.05) in values of packed cell volume (PCV), hemoglobin concentration (Hb) and red blood cell (RBC) count, and elevation in total white blood cell (WBC) count with insignificant reductions in serum total protein, albumin, and globulin levels. Alterations in aspartate aminotransferase, alanine transferase, alkaline phosphatase, and gamma glutamyl transferase activities, as well as in serum levels of urea, creatinine, glucose, cholesterol, and triglyceride levels, were not statistically significant. EEAC significantly restored (P \< 0.05) the PCV, Hb, RBC, and WBC as well as serum albumin, globulin, and total protein to normal values. Conclusion: The results of this study indicate that EEAC possess strong potentials to protect against toxicities induced by sodium arsenite.

}, keywords = {Ageratum conyzoides, Hematology, Histopathology, Liver, Serum Biochemistry, Sodium arsenite}, doi = {10.4103/0974-8490.178645}, author = {Olufunke Eunice Ola-Davies and Akinleye Stephen Akinrinde} }