@article {465, title = {In vivo anti-inflammatory and Antiarthritic Activities of Aqueous Extracts from Thymelaea Hirsuta,}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {June 2015}, pages = {213-216}, type = {Short Communication }, chapter = {213}, abstract = {

Background:\ The aerial parts of\ Thymelaeahirsuta\ (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.\ Objective:\ The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats.\ Materials and Methods:\ The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund{\textquoteright}s adjuvant-induced arthritis model.\ Results:\ The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60\% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40\% of inhibition. In arthritis model, the extract produced 85\% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72\%).\ Conclusion:\ These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.

}, keywords = {Antiarthritis, Antiinflammation, Medicinal plants, Thymelaea hirsuta, Wistar rats}, doi = {10.4103/0974-8490.150510 }, author = {Zora Azza and Mounia Oudghiri} }