@article {86, title = {Amentoflavone, New Hope against SARS-CoV-2: An Outlook through its Scientific Records and an in silico Study}, journal = {Pharmacognosy Research}, volume = {13}, year = {2021}, month = {June 2021}, pages = {149-157}, type = {Original Article}, chapter = {149}, abstract = {

Background: The plant-derived bioflavonoid amentoflavone has many important biological activities, among them remarkable antiviral effects, even against severe acute respiratory syndrome Coronavirus (SARS-CoV). It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) with an IC50 value of 8.3 μM. TMPRSS-2 activity is now thought to be the only factor necessary for cell entry and viral pathogenesis). In comparison, 3CLPRO is needed for COVID-19 replication and maturation during its life cycle. Aim: This study aims to perform an in silico study on amentoflavone activity against structural and non-structural severe acute respiratory syndrome coronavirus (SARS-CoV)-2 3-chymotrypsin-like protease (3CLPRO) and human transmembrane protease serine 2 (TMPRSS-2) proteins. Materials and Methods: Molecular docking studies were carried out using compounds against 3CLPRO and TMPRSS-2 proteins through the Swiss model, Uniport, PROCHECK, Swiss PDB viewer, PyMol, PyRx, and Desmond (Schr{\"o}dinger package) computerized software. Results: Amentoflavone showed strong interactions -9.5 and -7.4 kcal/mol with 3CLPRO and TMPRSS2 proteins, respectively. In any case, it had higher binding affinities than currently approved antiviral drugs, which are underutilized in coronavirus disease (COVID-19). Conclusion: Amentoflavone may be one of the potential leads (drug candidate) to fight human coronavirus, including SARS-CoV-2. Further in vivo studies are needed to support the findings of this study.

}, keywords = {3CLPRO, Amentoflavone, Antiviral potential, COVID-19, Molecular docking, Phenolic compounds, SARS-CoV-2, TMPRSS-2}, doi = {10.5530/pres.13.3.7}, author = {Rajib Hossain and Muhammad Torequl Islam and Pranta Ray and Divya Jain and Abu Saim Mohammad Saikat and Lutfun Nahar and Anupam Das Talukdar and Satyajit Sarker and Seyed Abdulmajid Ayatollahi and Miquel Martorell and Farzad Kobarfard and Nat{\'a}lia Cruz-Martins and Khattab Al-Khafaji and Anca Oana Docea and Daniela Calina} } @article {1005, title = {Preventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-19}, journal = {Pharmacognosy Reviews}, volume = {13}, year = {2021}, month = {October 2021}, pages = {173-191}, type = {Review Article}, chapter = {173}, abstract = {

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus {\textquotedblleft}Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2){\textquotedblright}. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale are now targeting approaches globally as a preventive care against SARS-CoV-2. Aim: This review is primarily focused on to deliver a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Experimental procedure: In this study, science mapping tool Bibliometrix R-package was used to perform bibliometric analysis and building data matrices for keywords co-occurrence investigation, country-wise scientific production; collaboration between the countries worldwide, co-word analysis on topic {\textquotedblleft}keywords associated with SARS-CoV-2 and medicinal plants{\textquotedblright}. Results and Conclusion: Our findings is to deliver a concise knowledge about the coronaviridae family, pathophysiology, possible targets for managing the SARS-CoV-2, in addition to potential medicinal plants and their phytoconstituents against COVID-19. Target-specific inflammatory pathways due to post infection of SARS e.g. NLRP3, p38-MAPK, Metallopeptidase Domain 17; endocytosis pathways e.g. Clathrin, HMGB1 pathways are primarily highlighted along with relevant interleukins and cytokines, which directly/indirectly triggering to immune system and play a significant role. Based on selective pathways and potential lead, the outcome of our elaborated study put forward selected Indian medicinal plants that hold a very high probability as preventive care in this global crisis.

}, keywords = {Biblioshiny, Coronavirus, COVID-19, Medicinal plants, Phytoconstituents, SARS-CoV-2}, doi = {10.5530/pres.13.4.10}, author = {Neelesh Kumar Nema and Ghouse Modin Nabeesab Mamdapur and Smitha Sarojam and Swapnil Devidas Khamborkar and Linson Cheruveettil Sajan and Sachithra Sabu and Baby Kumaranthara Chacko and Viju Jacob} }