@article {1210, title = {Development and Evaluation of Nephroprotective Polyherbal Formulation against Methotrexate Induced Toxicity in Sprague Dawley Rat}, journal = {Pharmacognosy Research}, volume = {16}, year = {2023}, month = {December 2023}, pages = {140-145}, type = {Original Article}, chapter = {140}, abstract = {

Methotrexate (MTX) is one of the most broadly used anti-cancer derivative of aminopterin and it is a first folic acid antagonist. Adult cancer, various malignancies, multiple sclerosis, dermatomyositis, sarcoidosis, psoriasis, rheumatoid arthritis, and severe inflammatory disorders are all commonly treated with MTX. Medicinal plants and herbs contribute, wide range of treatment and prevention from several diseases. Herbal formulations mean dosage form consisting of one or more plants prepared herbs in selected quantities to cure mitigate diseases, by treatment, prevention and sometimes use as a supplement. Petrida foetida is used as traditionally diarrhea, stomach ache and nutritional supplement etc. Vitis vinifera, the fruit is used for dietary and the leaves and seeds are used as several herbal therapy. The current study had carried out to evaluate the nephroprotective activity of leaves and seed extracts of Petrida foetida and Vetis venifera. Nephroprotective activities of ethanolic and aqueous extracts of Petrida foetida and Vitis vinifera seeds were examined against methotrexate induced Kidney damage in Sprague Dawley Rats. Biochemical parameter evaluates like Urea, Creatinine, Uric acid, Blood urea nitrogen, total protein like albumin, globulin was analyzed. Petrida foetida and Vitis venifera seeds extract of exhibited significant (p\<0.05) nephroprotective activity. Ethanolic seeds extract of Vitis vinifera and Petrida foetida menifest moderate activity upon Methotrexate induced Rat models. Study outcome shows the traditional-ethno medicinal use of Methotrexate as a potential source of Nephroprotective activity.

}, keywords = {Blood Urea Nitrogen (BUN)., Creatinine, Methotrexate (MTX), Nephroprotective activity, Polyherbal formulation (PHF)}, doi = {10.5530/pres.16.1.17}, author = {Arijit Chaudhuri and Udichi Kataria and Subodh Kumar Dubey and Neha Chopra and Devendra Dhanorya and Kamal Shah and Nagendra Singh Chauhan} } @article {443, title = {Effect of the Administration of Solanum nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {9}, year = {2017}, month = {November 2017}, pages = {325-332}, type = {Original Article}, chapter = {325}, abstract = {

Background: Our previous study showed antidiabetic effect of aqueous extract of Solanum nigrum Linn fruit (SNE). Objective: This study was designed to explore the antidiabetic and nephroprotective effects of SNE in diabetic rats. Materials and Methods: Animals were divided into nine groups to undergo two experiment protocols: Two groups served as nondiabetic controls (NDCs), while the other groups had diabetes induced with a single injection of streptozotocin. SNE-treated diabetic (D-SNE) and SNE-treated controls (NDC-SNE) received 1 g/L of SNE added to the drinking water and insulin-treated diabetic (D-I) for 8 weeks. Furthermore, there were four groups (D-SNE, NDC-SNE, D-I, D) in the second protocol to examine diabetic nephropathy (DN) for 16 weeks. Blood urea nitrogen (BUN), creatinine (Cr) magnesium, nitric oxide (NO), and malondialdehyde (MDA) levels were measured. Both kidneys were isolated to measure MDA, NO levels, and renal damage. Results: SNE could decrease blood glucose level in diabetic rats. In addition, SNE was more effective than insulin in controlling blood glucose. SNE could decrease BUN, Cr levels, and kidney weight and damage after 8 and 16 weeks of administration. Plasma and kidney levels of NO and MDA also decreased. Conclusion: Our results support the hypothesis that SNE could play a role in the management of diabetes and the prevention of DN.

}, keywords = {Blood glucose, Blood urea nitrogen, Creatinine, Diabetic nephropathy, Malondialdehyde, Solanum nigrum fruit}, doi = {10.4103/pr.pr_47_17}, author = {Fariba Azarkish and Kobra Hashemi and Ardashir Talebi and Mohammad Kamalinejad and Nepton Soltani and Nima Pouladian} }