@article {1184, title = {Crassocephalum crepidioides (Asteraceae) Benth S. Moore Leaves Fractions Attenuate Dyslipidemia and Atherogenic Indices in Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {761-770}, type = {Original Article}, chapter = {761}, abstract = {

Background: Diabetes mellitus, a metabolic and endocrine disorder, is associated with an impaired lipid profile that can result in increased atherogenic indices. The effects of the aqueous and hexane fractions of C. crepidioides leaves on the lipid profile and atherogenic indices of diabetic rats were investigated in this study. Materials and Methods: Varied concentrations (50-200 mg/kg body weight) of the aqueous (CAF) and hexane (CHF) fractions of C. crepidioides were assayed against streptozotocin-induced diabetic rats. Histological examinations of the pancreas were carried out using hematoxylin and eosin staining procedures. Experimental rats were randomly divided into 9 groups of 6 rats each and orally treated for 14 days. Results: The tested concentrations (50, 100 and 200 mg/kg) of CAF and CHF significantly (p \< 0.05) reduced plasma glucose (51.3-62.2\%), plasma and liver triglycerides (up to 50.5\% in plasma; 66.1\% in the liver), total cholesterol (up to 49.0\% in plasma; 35.3\% in the liver), low-density lipoprotein-cholesterol (up to 96.0 and 91.0\% in the plasma and liver), very low-density lipoprotein-cholesterol (up to 50.5\% in plasma; 55.0\% in the liver), and the atherogenic indices elevated by diabetes induction. The high-density lipoprotein-cholesterol concentrations were significantly increased (plasma: 73.60-127.60\%; liver: 108.70-152.5\%) in CAF and CHF-treated diabetic rats compared to the diabetic control. Histological examination showed improved tissue architecture in the pancreas of the diabetic-treated rats compared to the diabetic control. Conclusion: C. crepidioides leaf fractions possess hypolipidemic and anti-atherogenic activities. Therefore, the plant could be useful in managing diabetes, dyslipidemia, and cardiovascular conditions.

}, keywords = {Atherogenic indices, Diabetes mellitus, Dyslipidemia, Histological, Solvent fractions}, doi = {10.5530/pres.15.4.080}, author = {Opeyemi Oluwayemisi Ayodele and Funmilayo Dorcas Onajobi and Emeka Emea Okoro and Omolaja Osoniyi} } @article {424, title = {Anti-diabetic effects of ethanol extract of Bryonia laciniosa seeds and its saponins rich fraction in neonatally streptozotocin-induced diabetic rats}, journal = {Pharmacognosy Research}, volume = {7}, year = {2015}, month = {December 2014}, pages = {92-99}, type = {Original Article}, chapter = {92}, abstract = {

Context: Bryonia laciniosa Linn. (Cucurbitaceae) seed is used in traditional medicine for a number of ailments including metabolic disorders. Aim: This study evaluated the anti-diabetic action of the ethanol extract of B. laciniosa seeds and saponin fraction of it through its effect on hyperglycemia, dyslipidaemia and oxidative stress in neonatally streptozotocin (n-STZ)-induced diabetic rats (n-STZ diabetic rats). Materials and Methods: Ethanol extract (250 and 500 mg/kg; p.o.), saponin fraction (100 and 200 mg/kg; p.o.) and standard drug glibenclamide (3 mg/kg; p.o.) were administered to diabetic rats when the rats were 6 weeks old and continued for 10 consecutive weeks. Effects of ethanol extract and saponin fraction on various biochemical parameters were studied in diabetic rats. Results: The treatment with ethanol extract and saponin fraction for 10 weeks decrease in the levels of glucose, triglycerides, cholesterol, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein, serum urea, serum creatinine and diminished activities of aspartate transaminase, and alanine transaminase. The anti-hyperglycemic nature of B. laciniosa is probably brought about by the extra-\ the pancreatic mechanism as evidenced from unchanged levels of plasma insulin. B. laciniosa modulated effect of diabetes on the liver malondialdehyde, reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activity. Administration of ethanol extract and saponin fraction to diabetic rats showed a significant reversal of disturbed antioxidant status. Significant increase in SOD, CAT, and levels of GSH was observed in treated n-STZ diabetic rats. Conclusion: The present studyreveals the efficacy of B. laciniosa seed extract and its\  \ saponin fraction in the amelioration of n-STZ diabetic rats.

}, keywords = {Diabetes mellitus, Dyslipidemia, Hyperglycemia, Oxidative stress.}, doi = {10.4103/0974-8490.147217}, author = {Sandip B. Patel and Devdas Santani and Veena Patel and Mamta Shah} } @article {664, title = {Aloe barbadensis Mill. Formulation Restores Lipid Profile to Normal in a Letrozole-induced Polycystic Ovarian Syndrome Rat Model}, journal = {Pharmacognosy Research}, volume = {4}, year = {2012}, month = {april,2012}, pages = { 109-115}, type = {Original Article}, chapter = { 109}, abstract = {

Background: Polycystic ovarian syndrome (PCOS), characterized by ovulatory infertility and hyperandrogenism, is associated with metabolic complications such as dyslipidemia, insulin resistance and endothelial dysfunction. Almost 70\% PCOS women have abnormal serum lipid levels (dyslipidemia) and 50\% of these women are obese. Several classes of pharmacological agents have been used to manage dyslipidemia. However, studies have shown adverse effects associated with these drugs. In the light of alternate therapy, many medicinal herbs have been reported to show hypoglycemic, anti-hyperlipidemic potential. Aloe barbadensis Mill. or Aloe vera is reported as one such herb. This study was to evaluate the lipid correcting effect of Aloe vera gel (AVG) in a PCOS rat model. Materials and Methods: PCOS was induced in Charles Foster female rats by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days). All rats were hyperglycemic and 90\% rats also showed elevated plasma triglycerides, elevated LDL cholesterol levels, and lowered plasma HDL cholesterol levels indicative of a dyslipidemic profile. PCOS positive rats with an aberrant lipid profile were selected for treatment. An AVG formulation (1 ml (10 mg)/day, 30 days) was administered orally. Results and Conclusion: AVG treated PCOS rats exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol. The gel treatment also caused reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, bringing them to normal. In conclusion, AVG has phyto components with anti-hyperlipidemic effects and it has shown efficacy in management of not only PCOS but also the associated metabolic complication : dyslipidemia.

}, keywords = {Aloe vera gel, anovulation, anti-hyperlipidemic effect, Dyslipidemia, Hyperandrogenism, Infertility, Insulin resistance, Letrozole, Polycystic ovarian syndrome}, doi = {10.4103/0974-8490.94736}, author = {Bhavna N Desai and Radha H Maharjan and Laxmipriya P Nampoothiri} }