@article {1071, title = {Antihypertensive and Cardioprotective Property of Mimosa pudica Using Zebra Fish}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {July 2022}, pages = {333-337}, type = {Original Article}, chapter = {333}, abstract = {

Background: Increase in blood pressure is generally termed as hypertension which is one of the common causes of cardiovascular diseases. Despite the several treatment methods, hypertension stands to be the major concern in developing countries. Angiotensin converting enzyme is one of the key contributors in regulating blood pressure where improper activation of angiotensisn leads to hypertension. Mimosa pudica plant has been reported to exhibit several therapeutic properties and thus the current study was focused on evaluating antihypertensive property of phytochemicals found in the Mimosa pudica extract. Materials and Methods: Methanol extract of Mimosa pudica was examined for presence of potential phytochemicals by GC-MS and molecular docking studies were carried out using Autodock 4.2. Results: 07 phytochemicals were identified in the methanol extract of Mimosa pudica. Further molecular docking studies against angiotensin converting enzyme (ACE) was carried out and among the list of test compounds 9,12-octadecadienoic acid showed least binding energy with -6.6 kJ. Conclusion: Compounds selected as phytochemicals of Mimosa pudica from methanol extract of Mimosa pudica, specially 9,12-octadecadienoic acid considered for further evaluation of antihypertensive and cardioprotective activity.

}, keywords = {Angiotensin converting enzyme, Antihypertensive activity, Antihypertensive and cardioprotective activity, Methanol extract, Mimosa pudica}, doi = {10.5530/pres.14.3.49}, author = {Santhosh Kondajji Hanumanthappa and Joy Hoskeri Harris and Nivedita Pujari Sudhakar and Priyanka Ashoka and Manjunatha Hanumanthappa} } @article {380, title = {In vitro and In vivo Antioxidant Evaluation and Estimation of Total Phenolic, Flavonoidal Content of Mimosa pudica L}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {December 2015}, pages = {22-28}, type = {Original Article}, chapter = {22}, abstract = {

Objective: Mimosa pudica Linn. (Mimosaceae) is traditionally used as a folk medicine to treat various ailments including convulsions, alopecia, diarrhea, dysentery, insomnia, tumor, wound healing, snake bite, etc., Here, the study was aimed to evaluate the antioxidant potential of M. pudica leaves extract against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) (in vitro) and its modulatory effect on rat brain enzymes. Materials and Methods: Total phenolic, flavonoid contents, and in vitro antioxidant potential against DPPH radical were evaluated from various extracts of M. pudica leaves. In addition, ethyl acetate extract of Mimosa pudica leaves (EAMP) in doses of 100, 200, and 400 mg/kg/day were administered orally for 7 consecutive days to albino rats and evaluated for the oxidative stress markers as thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) from rat brain homogenate. Results: The ethyl acetate extract showed the highest total phenolic content and total flavonoid content among other extracts of M. pudica leaves. The percentage inhibition and IC50 value of all the extracts were followed dose-dependency and found significant (P \< 0.01) as compared to standard (ascorbic acid). The oxidative stress markers as SOD, CAT, and GSH were increased significantly (P \< 0.01) at 200 and 400 mg/kg of EAMP treated animals and decreased significantly the TBARS level at 400 mg/kg of EAMP as compared to control group. Conclusion: These results revealed that the ethyl acetate extract of M. pudica exhibits both in vitro antioxidant activity against DPPH and in vivo antioxidant activity by modulating brain enzymes in the rat. This could be further correlated with its potential to neuroprotective activity due to the presence of flavonoids and phenolic contents in the extract.

}, keywords = {2, 2-diphenyl-1-picrylhydrazyl, Brain homogenate, Flavonoids, Mimosa pudica, Oxidative stress}, doi = {10.4103/0974-8490.171099}, author = {Ganesh Patro and Subrat Kumar Bhattamisra and Bijay Kumar Mohanty and Himanshu Bhusan Sahoo} }