@article {368, title = {Protective Effect of Ferulago angulata (Schltdl.) Boiss. Hydroalcoholic Extract against Acetic Acid-induced Colitis in Rat: Role of Pro-inflammatory Cytokines}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {October 2018}, pages = {391-396}, type = {Original Article}, chapter = {391}, abstract = {

Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease with unknown etiology. Ferulago angulata (Schltdl.) Boiss. has been proposed as an efficacious treatment for gastrointestinal ulcers and UC in the traditional Persian medicine. Objective: In the present study, we investigated the possible protective effect of F. angulata (Schltdl.) Boiss. hydroalcoholic extract (FAE) against acetic acid-induced UC in rats. Materials and Methods: The aerial parts of FAE (50, 100, and 200 mg/kg) were administered orally after acetic acid induced-inflammatory bowel disease. On the 3rd day, animals were euthanized by an overdose of ether inhalation and the abdomen was rapidly dissected for macroscopic, histological, and biochemical (tumor necrosis factor [TNF]-α, interleukin-1β [IL-1β]) analyses. Results: All doses of F. angulata (Schltdl.) Boiss. extract ameliorated acetic acid-induced macroscopic and microscopic scores, except for 50 mg/kg. Furthermore, our observations were accompanied by a significant (P \< 0.05) suppression in the elevated amount of IL-1β and TNF-α. Conclusion: These findings demonstrated the beneficial effect of hydroalcoholic extract of F. angulata (Schltdl.) Boiss. in acetic acid-induced ulcerative lesions via anti-inflammatory, immunomodulatory, and mucosal healing properties. F. angulata (Schltdl.) Boiss. possesses promising protective function on colitis.

}, keywords = {Ferulago angulata (Schltdl.) Boiss, Herbal medicine, Inflammatory bowel disease, Inflammatory cytokines, Medicinal plant, Traditional medicine}, doi = {10.4103/pr.pr_9_18}, author = {Fatemeh Farzaei and Fatemeh Heydarpour and Mohammad Hosein Farzaei and Zahra Minush Siavash Haghighi and Zahra Abbasabadi and Ehsan Sadeghi} } @article {357, title = {Hepatoprotective, Antihyperlipidemic, and Anti-inflammatory Activity of Moringa oleifera in Diabetic-induced Damage in Male Wistar Rats}, journal = {Pharmacognosy Research}, volume = {9}, year = {2017}, month = {April 2017}, pages = {182-187}, type = {Original Article}, chapter = {182}, abstract = {

Background: The number of individuals with diabetes is increasing daily, and diabetes is presently estimated to affect about 422 million adults worldwide. Conventional drugs used to treat diabetes are not without severe side effects, accessibility, and affordability. This study elucidates the potential effects of Moringa oleifera (MO) leaves extract to manage and treat diabetes induced in male Wistar rats. Materials and Methods: Adult male Wistar rats were randomly divided into four groups (n = 12/group): NC {\textendash} nondiabetic rats (positive control), MO {\textendash} nondiabetic-treated rats, DM {\textendash} diabetic rats (negative control), DM + MO {\textendash} diabetic-treated rats. Hepatic enzymes and biochemical parameters as well as antioxidant capacity and inflammatory cytokine levels were assessed. Levels of low-density lipoprotein, high-density lipoprotein, and total cholesterol were evaluated. Results: Oral administration of methanolic extract of MO (250 mg/kg) to diabetic rats for 42 days showed a significant reduction in hepatic enzyme markers and normalized lipid profile parameters in the serum compared to normal control group. Treatment also increased the level of antioxidant capacity and alleviated inflammatory biomarkers of the liver. Histology sections of the liver tissue showed protective effect of MO in treated rats. Conclusions: MO showed hepatoprotective, anti-inflammatory, and lipid-lowering effects against streptozotocin-induced hepatotoxicity. Histological section demonstrated specific alterations in the liver of the diabetic and nondiabetic male Wistar rats while MO treatment revealed improvement in liver alterations.

}, keywords = {Diabetes, Hepatic enzymes, Inflammatory cytokines, Lipid profile, Moringa oleifera, Streptozotocin}, doi = {10.4103/0974-8490.204651}, author = {Elizabeth I Omodanisi and Yapo G Aboua and Novel N Chegou and Oluwafemi O Oguntibeju} }