@article {346, title = {Zingiber zerumbet Rhizomes Extract Exhibits Faster Open Wound Healing in Rats}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {October 2018}, pages = {354-360}, type = {Original Article}, chapter = {354}, abstract = {

Background: Zingiber zerumbet rhizome ethyl acetate extract (ZZRE) has the potential to be developed as a wound-healing agent with its profound anti-inflammatory property. Objective: This study was conducted to evaluate the wound healing effects of 5\% ZZRE on open wound in rats. Materials and Methods: Wistar rats (n = 90) were divided into three groups, negative control (treated with PBS), positive control (treated with solcoseryl gel), and 5\% ethyl acetate extract of Z. zerumbet, respectively. Wounds were induced on the rat{\textquoteright}s dorsal surface on day 0. Measurements of wound closure, total protein, uronic acid, hexosamine, cathepsin B, hydroxyproline, and histological observations were conducted on the wound tissues. Results: ZZRE-treated group showed increment in wound closure, protein, and hydroxyproline level. The uronic acid and hexosamine levels of ZZRE-treated wounds significantly increased on the 3rd day (P \< 0.05). Histological observations demonstrated formation of granulation tissue was faster and denser in ZZRE-treated group. Conclusion: ZZRE enhances open wound healing in rats and has potential to be developed as a healing agent in the future.

}, keywords = {Anti-inflammatory, Extract, Proteins, Rhizomes, Wound healing, Zingiber zerumbet}, doi = {10.4103/pr.pr_14_18}, author = {Asmah Hamid and Chong Pek Lian and Nur Hafiza Salleh Hudin and Ahmad Rohi Ghazali and Nurul Farhana Jufri} } @article {612, title = {Protective Effects of Picrorhiza Kurroa on Cyclophosphamide-induced Immunosuppression in Mice}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {January 2013}, pages = {30-35}, type = {Original Article }, chapter = {30}, abstract = {

Objective:\ To study the immunomodulatory effect of ethanolic and aqueous extract of the rhizomes of\ Picrorrhiza kurroa\ (Scrophulariaceae) in normal and immunosuppressed mice models.\ Materials and Methods:\ The rhizomes extract of\ Picrorrhiza kurroa\ was administered orally according to their body weight in mice. The study was carried out by various hematological and serological tests. The assessment of immunomodulatory activity on specific and non-specific immunity was studied by administration of test extract. The method of cyclophasphamide-induced immunosuppression was employed with slight modification to study the immunomodulatory potential of the extract. Plant extracts were administered by oral feeding canula to the test groups (groups III-VI), group I (control animals) and group II (model control animals) received same volume of normal saline (0.2 ml). Humoral antibody response to SRBC measurement of antibody titer by hemagglutination reaction was done. The mice belonging to the all groups were antigenically challenged with SRBC (0.5x10\ 9\ cells/ml/100 g) on 10\ th\ day intraparitoneally. Cellular immune response (Foot pad reaction test) the edema was induced by injecting SRBC (0.025x10\ 9\ cells) in left paw, and 0.025 ml of saline was injected in right paw.\ Results:\ The plant extract showed protective effects on humoral immunity. The change in percentage deduction in footpad volume was also found significant (P\<0.001). Administration of extract remarkably ameliorated both cellular and humoral antibody response.\ Conclusion:\ It is concluded that the test extracts possessed promising immunostimulant properties. But, the alcoholic extract is more potent than aqueous extract in producing delayed type hypersensitivity response.

}, keywords = {Hematological and Serological Tests, Immunomodulatory Activity, Picrorrhiza Kurroa, Rhizomes}, doi = {10.4103/0974-8490.105646 }, author = {Arshad Hussain and Wahab Shadma and Ali Maksood and Shahid Hussain Ansari} } @article {970, title = {Isolation of β-sitosterol Diglucosyl caprate from Alpinia galanga}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {September 2010}, pages = {264-266}, type = {Original Article}, chapter = {264}, abstract = {

Background: The purpose of present investigation to isolate β-sitosterol diglucosyl caprate from the rhizomes of Alpinia galanga. Methods: The methanolic extract of the rhizomes of plant Alpinia galanga was subjected to column chromatography and was eluted with ethyl acetate-methanol (99:1) to yield compound (AG5) β-sitosterol diglucosyl caprate. Various spectral techniques such as Ultraviolet (UV), Infrared (IR), Hydrogen Nuclear Magnetic Resonance (1HNMR), Carbon Nuclear Magnetic Resonance (13CNMR), and MASS spectrometry (MS), were employed to determine and elucidate. Results: Chemical and spectral investigation of extract furnished a new steroidal glycoside. Conclusion: The isolated compound β-sitosterol diglucosyl caprate could serve as a lead compound in synthesis of steroids.

}, keywords = {Alpinia galanga, Methanolic extract, Rhizomes, β-sitosterol diglucosyl caprate}, doi = {10.4103/0974-8490.69129}, author = {SB Jaju and NH Indurwade and DM Sakarkar and NK Fuloria and MD Ali and SP Basu} }