@article {1046, title = {Ameliorative Effect of Moringa oleifera Lam. Leaves Extract on the Sex Hormone Profile and Testicular Dysfunctions in Streptozotocin-induced Diabetic Wistar Rats}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {April 2022}, pages = {225-232}, type = {Original Article}, chapter = {225}, abstract = {

Background: Diabetes mellitus (DM) is associated with reproductive impairment. Medicinal plants and herbs are the rich source of antioxidants which may ameliorate diabetes-induced male reproductive dysfunctions and could play an important role in the management of diabetes induced male infertility. Objectives: The present study aimed to investigate the ameliorative effects of 70\% hydroalcoholic extract of Moringa oleifera Lam. leaves on sex hormone alterations and testicular dysfunction in diabetic rats. Materials and Methods: Diabetes mellitus (DM) in male rats was induced by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The induced diabetic rats were treated with three different doses (100, 250, and 500 mg/kg b.wt./day, orally for 60 days) of M. oleifera leaves extract. The results were compared with reference antidiabetic drug glibenclamide (5 mg/kg b.wt./day) treated diabetic rats. Reproductive hormones like testosterone, FSH and LH and oxidative stress parameters in the testicular tissues were determined. Histopathological and histomorphometric changes in the testis were also investigated. Results: Oral administration of three doses of M. oleifera leaves extract or glibenclamide in diabetic rats significantly improved serum sex hormones levels and restored histopathological and histomorphometric changes as compared to diabetic control rats. Furthermore, extract treatment in diabetic rats also reduced TBARS levels and improved the levels of antioxidant markers in the testicular tissue. These results were comparable with glibenclamide. Conclusion: Based on these results, it may be concluded that the extract of M. oleifera leaves possess significant antioxidant activities as well as play a pivotal role in modulating testicular dysfunction in diabetic rats.

Key words: Antioxidants, Histomorphometric, Moringa oleifera, Streptozotocin, Testis, Testosterone,

}, doi = {10.5530/pres.14.2.32}, author = {Ram Niwas Jangir and Gyan Chand Jain} } @article {290, title = {Evaluation of Protective Effects of Hydroalcoholic Extract of Cassia fistula Linn. Pod on Pancreas in Streptozotocin-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {April 2018}, pages = {212}, type = {Original Article}, chapter = {205}, abstract = {

Background: Diabetes mellitus (DM) is associated with oxidative stress. Medicinal plants and herbs are the rich sources of antioxidants which ameliorate oxidative stress-induced diabetic complications and could play an important role in the management of diabetes. Objective: The present study aimed to evaluate the protective effects of 70\% ethanolic extract of Cassia fistula pod on pancreas in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (60 mg/kg b.wt.). The diabetic rats were administered orally with C. fistula pod extract at three different doses (100, 250, and 500 mg/kg b.wt./day) for 60 days. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./ day) treated rats. Relative pancreatic weight and serum insulin level were determined. Histopathological changes and oxidative stress parameters, i.e., lipid peroxidation (thiobarbituric acid reactive substance [TBARS]) and antioxidative defense markers (superoxide dismutase, catalase, glutathione, and ascorbic acid), in the pancreas were investigated. Results: Oral administration of C. fistula pod extract (100, 250, and 500 mg/kg b.wt./day) or glibenclamide in diabetic rats significantly improved serum insulin level, total protein concentration, relative pancreatic weight, and mean diameter of islets of Langerhans as compared to diabetic control rats. Furthermore, treatment with extract also reduced TBARS levels and improved the levels of antioxidant markers in the pancreas. The histomorphological picture of the pancreas showed marked restoration of islets morphology. These results were comparable with glibenclamide. Conclusions: The results of the present study showed that C. fistula pod extract possesses significant antidiabetic activity though enhanced insulin secretion, improvement of antioxidative status of pancreas, and preservation of the integrity of pancreatic islets.

}, keywords = {Antioxidants, Cassia fistula, Insulin, Pancreas, Streptozotocin}, doi = {10.4103/pr.pr_95_17}, author = {Ram Niwas Jangir and Gyan Chand Jain} }