@article {172, title = {Antilipidemic Properties of Calpurnia aurea Leaf Extract on High-Fat Diet Induced Hyperlipidemia}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {November,2019}, pages = {389-395}, type = {Original Article}, chapter = {289}, abstract = {

Background: Hyperlipidemia is described by raised in the plasma lipids including triglycerides (TG), cholesterols, cholesterol esters, phospholipids as well as plasma lipoproteins, for example, very low-density lipoprotein (LDL), LDL, and reduction in the circling high-density lipoprotein (HDL) levels. Objective: To explore the antilipidemic properties of the hydromethanolic extract of Calpurnia aurea (HMECA) leafs against high-fat diet-induced hyperlipidemic male albino Wistar rats. Materials and Methods: Thirty albino Wistar rats of 60{\textendash}75 days and weights of 150{\textendash}200 g were isolated arbitrarily into six groups of five each. Group I fed with normal diet in as typical control, Group II got high-fat-eating routine (48.8\% fat w/w) containing fat produced using hamburger fat and blended with hydrogenated vegetable oil, Group III fed with high fat diet plus 3.5 mg/kg/day atorvastatin as standard control, and the remaining Groups IV, V, and VI fed with high fat diet along with different does of HMECA at 200, 300, and 400 mg/kg/day separately for 60 days. Food intake, body weight, body mass index, serum lipid profiles, and liver histopathology were studied. Results: The results of this investigation exposed that HMECA has dose-dependent antilipidemic exercises. HMECA treatment of 400 mg/ kg caused a noteworthy bringing down of P \< 0.05 of serum LDL from 28.53 {\textpm} 12.2 mg/dl to 9.70 {\textpm} 5.77 mg/dL; the serum cholesterol level from 92.00 {\textpm} 13.0 mg/dl to 60.33 {\textpm} 8.60 mg/dl; the serum TG leve1 from 84.73 {\textpm} 19.4 mg/dl to 71.83 {\textpm} 13.0 mg/dl mg/dl; and increased the serum HDL-cholesterol levels from 11.66 {\textpm} 1.23 mg/dl to 29.66 {\textpm} 1.52 mg/dl. At the medium dosage of 300 mg/kg, it was not successful as 400 mg/ kg and at the insignificant dosage of 200 mg/kg brought numerical contrast not statistically noteworthy among the serum lipid profile. Conclusion: This research discovered that the HMECA possesses a significant antilipidimic activity in dose dependent manner. The molecular mechanism of antilipidemic exercises of this medication should be contemplated.

}, keywords = {Antilipidemia, Calpurnia aurea, High-fat diet, Hyperlipidemia, Lipid profile.}, doi = {10.4103/pr.pr_10_18}, author = {Welde Mengistu and Seifu Daniel and Natesan Gnanasekaran} }