@article {1430, title = {Natural Marine Species Bioactive Compounds and their Ethnopharmacological Approach from Ecological Biodiversity: Sustainable Therapeutic Properties}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {697-706}, type = {Review Article}, chapter = {697}, abstract = {

Marine ecosystems are a rich source of bioactive compounds, offering immense potential for therapeutic applications. Research studies from pubmed, Google scholar, Science direct, databases provided derived from diverse organisms such as algae, sponges, mollusks, and marine microorganisms, these natural products exhibit a wide range of pharmacological properties, including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Ethnopharmacological knowledge, deeply rooted in traditional practices, serves as a valuable guide for identifying the medicinal potential of marine resources, creating a bridge between traditional wisdom and modern drug discovery. Recent advancements in biotechnological tools and sustainable bioprospecting have accelerated the discovery, isolation, and development of these bioactive compounds into promising therapeutic agents. Despite these advancements, significant challenges remain. The exploration of marine biodiversity is still limited, with many ecosystems, such as deep-sea and polar regions, largely unexplored. Sustainable harvesting practices, understanding the mechanisms of action and pharmacokinetics of marine bioactive, and mitigating the environmental impacts of large-scale extraction are critical issues. Additionally, the integration of ethnopharmacological knowledge with modern scientific approaches requires systematic validation and documentation. This review emphasizes the therapeutic potential of marine bioactive compounds, highlights the importance of sustainable and ethical bioprospecting practices, and identifies key research gaps that must be addressed to fully harness the benefits of marine biodiversity for global health.

}, keywords = {Biodiversity, Ethnopharmacology, Marine drugs, Marine organism, Marine Pharmacognosy, Secondary metabolites}, doi = {10.5530/pres.20252162}, author = {Paramita Ganguly and Puja Saha and Sandip Chatterjee and Prangya Paramita Pati} } @article {1459, title = {Potent in vitro Antioxidant, Antimicrobial, and Antidiabetic Effects of a Polyherbal Mixture: Evidence from 3T3-L1, β-TC6, and C2C12 Cell Line Studies}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {961-972}, type = {Original Article}, chapter = {961}, abstract = {

Aim and Objectives: The traditional plants Plumeria pudica, Podranea ricasoliana, and Leea macrophylla have been used for their medicinal properties since ancient times. Our main objective is to identify the preliminary chemicals of these plant leaves to prepare a polyherbal mixture and apply it for in vitro DPPH, H2O2, and NO scavenging free radical antioxidants test with antibacterial study and evaluated for its in vitro antidiabetic potential using 3T3-L1, β-TC6, and C2C12 cell lines. Materials and Methods: The macroscopic study as well as the preliminary phytochemical screening of these plants, possess many numbers of metabolites that are responsible for anti-inflammatory and anti-oxidant properties. The plant extract{\textquoteright}s hydrogen peroxide scavenging activity was assessed by measuring absorbance at 230 nm using a UV-vis spectrophotometer. The disc plate technique uses antibiotics to decrease the various gram-positive and negative bacterial properties. Ethanol-based extract of Polyherbal Mixture (PHM) was subjected to phytochemical analysis. The increase of glucose uptake in 3T3L1 cells (a) and C2C12 myoblast cells over the treatment of PHM extract at varying concentrations ranging from 10 to 500 μg/mL. Metformin and Insulin-stimulated glucose uptake were considered positive controls. Experiments were conducted in triplicate. Results: The IC50 values of the DPPH, NO, and H2O2 scavenging assays revealed that the test compounds were less potent than the standard drugs, yet they still exhibited satisfactory free radical scavenging activity. The ethanolic extract of the Polyherbal Mixture (PHM) showed antibacterial activity that was slightly less potent than the standard antibiotic ciprofloxacin, yet still produced satisfactory results with comparable inhibition zones. Furthermore, the IC50 values of the test drug PHM (16.71, 12.0, and 20.8 μg/mL) and the standard drug ascorbic acid (7.07, 6.07, and 8.0 μg/mL) indicate that PHM possesses antioxidant scavenging activity. The zone of inhibition of PHM was satisfactory as compared to the standard drug during the antimicrobial study. Specifically, in 3T3-L1 cells, PHM-500 (2.9{\textpm}0.25), metformin (2.8{\textpm}0.41), and insulin (5.9{\textpm}0.43) increased glucose uptake compared to control. Similarly, in C2C12 myoblasts, PHM-500 (4.37{\textpm}0.28), metformin (4.91{\textpm}0.34), and insulin (6.77{\textpm}0.32) showed increased glucose uptake. Conclusion: The poly-herbal mixture is expected to exhibit beneficial anti-microbial, anti-oxidant, and anti-diabetic activities, making it a unique and unpublished formulation.

}, keywords = {and C2c12 Cell Lines, Antibacterial, Antidiabetic Potential Using 3t3-L1, Antioxidant, Phytochemical screening, Β-Tc6}, doi = {10.5530/pres.20252220}, author = {Dharmendra Pradhan and Santosh Kumar Ranajit and Prafulla Kumar Sahu and Sandip Chatterjee} }