@article {1436, title = {Phytochemical Profile and Pharmacological Insights of Anisomeles malabarica Leaf Extracts: A Comprehensive Review}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {769-777}, type = {Review Article}, chapter = {769}, abstract = {

Anisomeles malabarica, a medicinal plant native to India and Southeast Asia, has been traditionally used to treat various health issues, including fever, wounds, respiratory, and digestive disorders. This review provides an overview of the bioactive compounds found in the leaves of Anisomeles malabarica and their therapeutic applications. Leaves are rich in diverse classes of phytochemicals, including flavonoids, phenolic acids, terpenoids, sterols, and essential oils. The extraction methods used in the study include maceration and Soxhlet extraction, and their chemical compositions form the basis of their pharmacological activities. It shows excellent antimicrobial activity against many fungi and bacteria. These anti-inflammatory effects may explain the observed antiepileptic effects. The strong antioxidant properties of A. malabarica stemming from its flavonoids and phenolic compounds allows for the possibility of treating diseases concerning oxidative stress. Traditionally, Anisomeles malabarica has shown promise in the management of diabetes and malaria. Certainly, in view of its therapeutic value, the operational challenges in this study include variations in bioactive compound quantities, the absence of standardized extraction methods, and clinical inadequacy. Future recommendations should include extensive metabolomic studies, standardization of extraction and purification methods, clinical trials, and assessment of mechanisms related to behavioral effects to substantiate its health claims in modern science for safety and efficacy for human consumption.

}, keywords = {Anisomeles malabarica, anticancer, Antimicrobial, Bioactive compounds, Therapeutic applications.}, doi = {10.5530/pres.20252254}, author = {Madhivardhana. P and Kiranvikas. E and Ziya Huq Khan. Z and Mangal Raj. S} } @article {1353, title = {Study of in silico and in vitro Anthelmintic Activity of Ethanolic Extract of Artemisia pallens Wall Ex. DC}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {143-153}, type = {Original Article}, chapter = {143}, abstract = {

Background: Helminths, a disease that affects all ages, are being treated with medicinal herbs such as Artemisia pallens Wall. ex DC, a traditional plant material with phytomedicinal properties. Objectives: The study assesses the anthelmintic activity of ethanolic plant material extract against common gastrointestinal helminths and explores its potential as an alternative or complementary treatment for parasitic infections. Materials And Methods: Indian adult earthworm Pheritima posthuma was employed to screen anthelmintic activity. Worms were exposed to different concentration 10 mg/mL, 20 mg/mL, 50 mg/mL, 80 mg/mL and 100 mg/mL concentrations of extract and standard drug, albendazole. Molecular docking for the observation of compounds which had higher activities towards the NADH-Fumarate reductase enzyme. From the database, the compounds with higher docking fitness scores determined using the Auto Dock software version 1.5.6. Further, the ADME/T profiling was done on Swiss ADME Analysis and also on pkCSM software tool. Results: Preliminary phytochemical analysis of EEAP indicated the presence of alkaloids, flavonoids, tannins, phenols, terpenoids. The anthelmintic potential of A. pallens extract, which showed strong antihelminthic activity in combination with adult Pheritima posthuma that produced paralysis and death at an earlier period as compared to albendazole, while the molecular docking study found good binding scores in the range of -5.15 kcal/mol to -9.6 kcal/mol with the fumarate reductase enzyme. Conclusion: The study confirmed the potential anthelmintic activity of Artemisia pallens. Wall extract, with compounds showing favorable binding scores indicating potential for forthcoming clinical investigations.

}, keywords = {Anthelmintic, Artemisia pallens, AutoDock, Fumarate reductase, Pheretima posthuma}, doi = {10.5530/pres.20251960}, author = {Madhivardhana. P and J. Vidhya Bharathy and S. Ajay Karthikeyan} }