@article {1219, title = {A Comprehensive Review of Therapeutical and Ethnobotanical Aspects, Phytoconstituent and Pharmacological Activity of Aesculus indica}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {203-210}, type = {Review Article}, chapter = {203}, abstract = {

Aesculus indica Wall. Ex Camb. Hook, a member of the Hippocastanaceae family, exhibits robust growth in colder climates worldwide, showcasing its remarkable adaptability. Within its various components lie a diverse array of constituents, each harboring a treasury of advantageous compounds that have found utility across a spectrum of applications. These applications encompass the amelioration of gastrointestinal disturbances, facilitation of hemostasis, management of diabetes, and mitigation of various dermatological afflictions. Through a comprehensive synthesis of information gleaned from an array of authoritative sources including meticulous literature surveys, our study provides a thorough dissection. It traverses the multifaceted tapestry of this plant{\textquoteright}s applications, devlopes into its intricate chemical composition, and elucidates its nuanced effects on human health and well-being. This compendium stands as an invaluable reservoir, poised to aid and embolden scientists and researchers engaged in the exploration of natural products. Its content, meticulously aggregated and meticulously crafted, promises a resourceful springboard for their scholarly inquiries while assuring originality and authenticity in their pursuits.

}, keywords = {Aesculus indica, Anti-diabetic activite, Antimicrobial activity., Antioxidant, Pharmacognosy, Pharmacology activity, Phytochemistry}, doi = {10.5530/pres.16.2.26}, author = {Shubham Anand and Arijit Chaudhuri and Neha Chopra and Devendra Dhanorya and Manoj Kumar Bajhaiya and Gujjala Sai Sri Harsha and Vijeta Bhattacharya and Udichi Kataria and Gaurav Kumar} } @article {1239, title = {A Comprehensive Study on Achyranthes aspera and Aesculus indica Hepatoprotective and Nephroprotective Activities of against Cisplatin Induced Rodent Model}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {315-323}, type = {Original Article}, chapter = {315}, abstract = {

Aim: In our present research, we aimed to evaluate the protective effects of HF1, HF2, and HF3 against liver and kidney damage induced by Cisplatin in Sprague Dawley rats. The ethanol fraction of the plant underwent initial phytochemical analysis followed by subsequent in vivo screenings. The findings from the phytochemical investigation indicated that HF2 demonstrated a more potent hepatoprotective and renal protective activity. Background: Anti-cancer medications have the potential to inflict harm on the liver and kidneys, underscoring the crucial need for hepatoprotection in safeguarding liver function. Among the elderly population, liver and kidney impairment account for 10\% of chronic hepatitis and renal failure cases. The decline induced by anti-cancer drugs has not been thoroughly assessed, partly due to its underestimation in clinical practice and challenges in making a precise diagnosis. While chemotherapeutic agents can induce liver toxicity through various mechanisms and lead to different types of liver and kidney injuries, they share the common trait of being both hepatotoxic and nephrotoxic. Materials and Methods: The dried peels of Aesculus indica fruits and powdered leaves of Achyranthes aspera were subjected to Soxhlet extraction using 95\% ethanol. Rat will randomly into five groups (six rats per each group). cisplatin group will give a single injection of cisplatin (20 mg per Kg, i.p) on the first 1st, 7th, 14th, 21th and 28th days. Hepatic function was assessed by measuring blood bilirubin, Glutamate Oxaloacetate Transferase (SGOT), and Glutamate Pyruvate Transaminase (SGPT). Blood tests were used to check the function of the liver and kidneys. Results: These results collectively suggest that HF1, HF2, and HF3 serve as a potential reservoir of novel secondary metabolites. Moreover, this study has laid the groundwork for future research in pharmacological studies, particularly in the development of potent biomedicine for the treatment of various chronic diseases. Conclusion: The current study has also proved the way for future pharmacological investigations, particularly with regard to all medications derived from the creation of powerful medicines for the management of various chronic conditions.

}, keywords = {Cisplatin, Hepatoprotective, Herbal formulation., nephroprotective}, doi = {10.5530/pres.16.2.40}, author = {Arijit Chaudhuri and Udichi Kataria and Shubham Anand} } @article {1210, title = {Development and Evaluation of Nephroprotective Polyherbal Formulation against Methotrexate Induced Toxicity in Sprague Dawley Rat}, journal = {Pharmacognosy Research}, volume = {16}, year = {2023}, month = {December 2023}, pages = {140-145}, type = {Original Article}, chapter = {140}, abstract = {

Methotrexate (MTX) is one of the most broadly used anti-cancer derivative of aminopterin and it is a first folic acid antagonist. Adult cancer, various malignancies, multiple sclerosis, dermatomyositis, sarcoidosis, psoriasis, rheumatoid arthritis, and severe inflammatory disorders are all commonly treated with MTX. Medicinal plants and herbs contribute, wide range of treatment and prevention from several diseases. Herbal formulations mean dosage form consisting of one or more plants prepared herbs in selected quantities to cure mitigate diseases, by treatment, prevention and sometimes use as a supplement. Petrida foetida is used as traditionally diarrhea, stomach ache and nutritional supplement etc. Vitis vinifera, the fruit is used for dietary and the leaves and seeds are used as several herbal therapy. The current study had carried out to evaluate the nephroprotective activity of leaves and seed extracts of Petrida foetida and Vetis venifera. Nephroprotective activities of ethanolic and aqueous extracts of Petrida foetida and Vitis vinifera seeds were examined against methotrexate induced Kidney damage in Sprague Dawley Rats. Biochemical parameter evaluates like Urea, Creatinine, Uric acid, Blood urea nitrogen, total protein like albumin, globulin was analyzed. Petrida foetida and Vitis venifera seeds extract of exhibited significant (p\<0.05) nephroprotective activity. Ethanolic seeds extract of Vitis vinifera and Petrida foetida menifest moderate activity upon Methotrexate induced Rat models. Study outcome shows the traditional-ethno medicinal use of Methotrexate as a potential source of Nephroprotective activity.

}, keywords = {Blood Urea Nitrogen (BUN)., Creatinine, Methotrexate (MTX), Nephroprotective activity, Polyherbal formulation (PHF)}, doi = {10.5530/pres.16.1.17}, author = {Arijit Chaudhuri and Udichi Kataria and Subodh Kumar Dubey and Neha Chopra and Devendra Dhanorya and Kamal Shah and Nagendra Singh Chauhan} }