@article {1511, title = {Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1315-1327}, type = {Original Article}, chapter = {1315}, abstract = {

Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thoroughly explore Achyranthes aspera pharmacological potential. Materials and Methods: Antibacterial activity against a panel of bacterial strains was assessed using the disc diffusion method. To ascertain cell viability in cancer cell lines, anti-cancer activity was assessed using the MTT assay. The antioxidant activity of the plant extract was assessed by its capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Results: Achyranthes aspera extract showed encouraging antibacterial efficacy against specific bacterial strains, however not as strong as the common antibiotic, ciprofloxacin. The MTT assay indicated possible anti-cancer efficacy by showing a notable dose-dependent reduction in cancer cell lines{\textquoteright} cell viability. Through the scavenging of free radicals, the extract from Achyranthes aspera also demonstrated strong antioxidant activity. Conclusion: The pharmacological potential of Achyranthes aspera is strongly supported by this investigation, confirming its historic use in treating a variety of illnesses. Promising antioxidant, antimicrobial and anti-cancer properties were demonstrated by the plant extract. In order to determine the bioactive components, clarify the underlying mechanisms of action, assess the protection and efficacy of Achyranthes aspera extracts in preclinical, clinical contexts, these findings call for additional research.

}, keywords = {Achyranthes aspera, Anti-cancer, Anti-microbial, Antioxidant}, doi = {10.5530/pres.20252314}, author = {Arijit Chaudhuri and Biswajit Dash and Ashish Sarkar and Afrin Alam and Ayush Garg and Shivani Devi and Ankita Sharma and Varsha Chauhan and Tanbeer Kaur and Yashna Bawa} } @article {1440, title = {Pharmacological Investigation of Actinidia deliciosa Extract in NSAIDs Induced Gastric Ulcer in Rodent Model}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {801-815}, type = {Review Article}, chapter = {801}, abstract = {

NSAIDs or non opoidal agents are commonly employed to treat rubor, dolor, relieve pain, but they often cause Gastrointestinal (GI) side effects, including gastritis, ulceration and bleeding. Natural products have emerged as potential alternatives or adjuncts to conventional treatments. The purpose of this study is to look at how Actinidia deliciosa (kiwi) extract protects against gastric ulcer brought on by NSAIDs. Background: NSAIDs are a group of pharmaceutical medications that are usually employed to treat rubor and dolor along with pyrexia as well as give a certain analgesic action at a certain therapeutic dose. At certain doses it is also used treat some sort of discomfort. While effective for these purposes, NSAIDs can also cause significant Gastrointestinal (GI) side effects, leading to conditions like gastritis, ulcers and even bleeding. This condition is known as NSAIDs-induced gastric ulcer. Materials and Methods: Rats will be divided into control, NSAIDs-induced gastric ulcer and NSAIDs-induced gastric ulcer treated with Actinidia deliciosa extract groups. The NSAIDs-induced gastric ulcer model will be established using indomethacin. The extract will be administered orally at various doses for a specified duration. GI damage will be assessed by measuring ulcer index, histological examination and biochemical markers (e.g., myeloperoxidase, malondialdehyde). The antioxidant activity of the extract will also be evaluated. Results: Preliminary findings suggest that Actinidia deliciosa extract significantly reduces NSAIDs-induced GI damage. It may exert its protective effects through antioxidant properties, inhibition of inflammatory mediators and mucosal barrier enhancement. Conclusion: Actinidia deliciosa extract shows promise as a potential natural agent for preventing NSAIDs-induced gastric ulcer. Further studies are warranted to elucidate the underlying mechanisms, determine the optimal dosage and administration route.

}, keywords = {Actinidia deliciosa, Antioxidant, Diclofenac, Gastric ulcer, Gastric ulcers, NSAIDs}, doi = {10.5530/pres.20252087}, author = {Arijit Chaudhuri and Arushi A and Manisha Dhiman and Anshul Thakur and Risha Kumari and Seema Devi and Shilpa Thakur and Ayusha A and Prince P and Nidhika N} } @article {1219, title = {A Comprehensive Review of Therapeutical and Ethnobotanical Aspects, Phytoconstituent and Pharmacological Activity of Aesculus indica}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {203-210}, type = {Review Article}, chapter = {203}, abstract = {

Aesculus indica Wall. Ex Camb. Hook, a member of the Hippocastanaceae family, exhibits robust growth in colder climates worldwide, showcasing its remarkable adaptability. Within its various components lie a diverse array of constituents, each harboring a treasury of advantageous compounds that have found utility across a spectrum of applications. These applications encompass the amelioration of gastrointestinal disturbances, facilitation of hemostasis, management of diabetes, and mitigation of various dermatological afflictions. Through a comprehensive synthesis of information gleaned from an array of authoritative sources including meticulous literature surveys, our study provides a thorough dissection. It traverses the multifaceted tapestry of this plant{\textquoteright}s applications, devlopes into its intricate chemical composition, and elucidates its nuanced effects on human health and well-being. This compendium stands as an invaluable reservoir, poised to aid and embolden scientists and researchers engaged in the exploration of natural products. Its content, meticulously aggregated and meticulously crafted, promises a resourceful springboard for their scholarly inquiries while assuring originality and authenticity in their pursuits.

}, keywords = {Aesculus indica, Anti-diabetic activite, Antimicrobial activity., Antioxidant, Pharmacognosy, Pharmacology activity, Phytochemistry}, doi = {10.5530/pres.16.2.26}, author = {Shubham Anand and Arijit Chaudhuri and Neha Chopra and Devendra Dhanorya and Manoj Kumar Bajhaiya and Gujjala Sai Sri Harsha and Vijeta Bhattacharya and Udichi Kataria and Gaurav Kumar} }