@article {1336, title = {Ethanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {60-69}, type = {Original Article}, chapter = {60}, abstract = {

Background: The chemotherapeutic agents used to treat cancer are known to possess potent adverse effects like nephrotoxicity and hepatotoxicity among others. Objectives: The aim of this current study happened to be the isolation of phytoconstituent from Achyranthes aspera and assess the protective effect of the compound against cisplatin-induced hepato- and nephrotoxicity in rats. Materials and Methods: Toluene: Ethyl Acetate (9:1) was used as the solvent system to isolate the phenolic compound from ethanolic extract of the leaves and stem of A. aspera. The isolated compounds were studied using mass spectroscopy, 1H NMR, FT-IR and UV. The effect of the isolated phenolic was assessed by study of various factors like body weight, organ weight, serum biomarkers and histopathological studies. Results: The treatment of cisplatin led to a significant increase the weight of the organs, hepatic and kidney biomarkers in serum suggesting toxicity whereas the the isolated component reversed the elevated levels (p\<0.05 compared to positive control). Conclusion: It could be concluded from the results that pretreatment with isolated component (coumarin) was able to attenuate the hepato-and nephron-toxicity induced by anticancer drug cisplatin.

}, keywords = {Achyranthes aspera, Cisplatin, Hepatotoxicity, Isolation, Nephrotoxicity}, doi = {10.5530/pres.20251905}, author = {Arijit Chaudhuri and Udichi Kataria and Anurag Dubey} } @article {1239, title = {A Comprehensive Study on Achyranthes aspera and Aesculus indica Hepatoprotective and Nephroprotective Activities of against Cisplatin Induced Rodent Model}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {April 2024}, pages = {315-323}, type = {Original Article}, chapter = {315}, abstract = {

Aim: In our present research, we aimed to evaluate the protective effects of HF1, HF2, and HF3 against liver and kidney damage induced by Cisplatin in Sprague Dawley rats. The ethanol fraction of the plant underwent initial phytochemical analysis followed by subsequent in vivo screenings. The findings from the phytochemical investigation indicated that HF2 demonstrated a more potent hepatoprotective and renal protective activity. Background: Anti-cancer medications have the potential to inflict harm on the liver and kidneys, underscoring the crucial need for hepatoprotection in safeguarding liver function. Among the elderly population, liver and kidney impairment account for 10\% of chronic hepatitis and renal failure cases. The decline induced by anti-cancer drugs has not been thoroughly assessed, partly due to its underestimation in clinical practice and challenges in making a precise diagnosis. While chemotherapeutic agents can induce liver toxicity through various mechanisms and lead to different types of liver and kidney injuries, they share the common trait of being both hepatotoxic and nephrotoxic. Materials and Methods: The dried peels of Aesculus indica fruits and powdered leaves of Achyranthes aspera were subjected to Soxhlet extraction using 95\% ethanol. Rat will randomly into five groups (six rats per each group). cisplatin group will give a single injection of cisplatin (20 mg per Kg, i.p) on the first 1st, 7th, 14th, 21th and 28th days. Hepatic function was assessed by measuring blood bilirubin, Glutamate Oxaloacetate Transferase (SGOT), and Glutamate Pyruvate Transaminase (SGPT). Blood tests were used to check the function of the liver and kidneys. Results: These results collectively suggest that HF1, HF2, and HF3 serve as a potential reservoir of novel secondary metabolites. Moreover, this study has laid the groundwork for future research in pharmacological studies, particularly in the development of potent biomedicine for the treatment of various chronic diseases. Conclusion: The current study has also proved the way for future pharmacological investigations, particularly with regard to all medications derived from the creation of powerful medicines for the management of various chronic conditions.

}, keywords = {Cisplatin, Hepatoprotective, Herbal formulation., nephroprotective}, doi = {10.5530/pres.16.2.40}, author = {Arijit Chaudhuri and Udichi Kataria and Shubham Anand} }