@article {1161, title = {Evaluation of Protective Effects of Polyphenols of the Marine Brown Alga Ecklonia cava against Potassium Bromate Induced Nephrotoxicity in Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {544-550}, type = {Original Article }, chapter = {544}, abstract = {

Background: Ecklonia cava is a kelp (brown algae) genus belonging to Lessoniaceae with plenty of Eckol-type phlorotannins. It exhibits antioxidant, anti-inflammatory, and antibacterial activity. Objectives: This study investigated Ecklonia cava (EC) polyphenols for their protective effects against KBrO3-induced nephrotoxicity in rats. Materials and Methods: The polyphenolic fraction was isolated from EC. Group, I was control (untreated), and group II was administered KBrO3 (135 mg/kg b.w) intragastric for four weeks. Group III was administered ECPP (200 mg/kg b.w) concurrently with KBrO3 (135 mg/kg b.w) orally, and Group VI was administered Rutin (100 mg/ kg b.w) along with KBrO3 (135 mg/kg b.w) orally. The protective effects of ECPP on KBrO3-induced nephrotoxicity in rats were assessed for the biochemical parameters of serum, various antioxidant enzymes, and histopathological changes in kidneys. Results: The level of serum of Blood Urea Nitrogen (BUN), uric acid, and creatinine was suggestively augmented (p\<0.001) when treated by KBrO3. The activity of antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, and FRAP (ferric ion reducing antioxidant parameter) were diminished (p\<0.001). At the same time, lipid peroxidation and nitric oxide were raised (p\<0.001) with KBrO3 treatment in the kidneys. In addition, the protein carbonyl level was amplified (p\<0.001) with KBrO3 administration. Histological studies presented renal damage in KBrO3-treated animals where tissue injury was abridged in ECPP pretreatment groups. Conclusion: These results suggest that ECPP functions as an antioxidant in vivo by scavenging reactive oxygen species, which helps preclude oxidative renal injury in rats treated with KBrO3.

}, keywords = {Antioxidant, Ecklonia cava, Nephroproductive activity, Polyphenols, Potassium bromate.}, doi = {10.5530/pres.15.3.057}, author = {Moqbel Ali Moqbel Redhwan and Suman Samaddar and Hariprasad MG and Sumaia Abdulbari Ahmed Ali Hard and Gitima Deka and Anyembe Godfrey} } @article {1189, title = {Hepatoprotective Assessment of Copper Calx against Anti-Tubercular Drug-induced Hepatotoxicity in Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {806-812}, type = {Original Article}, chapter = {806}, abstract = {

Background: Anti-Tubercular Drugs (ATDs), while effective in treating tuberculosis, are associated with hepatotoxicity, leading to liver damage and complications. Calx of Copper, a traditional Ayurvedic preparation, has shown potential hepatoprotective properties. Objectives: To investigate the potential hepatoprotective role of Calx of Copper in mitigating ATD-induced hepatotoxicity and to examine its impact on liver function markers and histopathological changes in rats. Materials and Methods: Thirty male Wistar rats were randomly divided into five groups (n=6 per group): control, ATD, Calx of Copper, ATD+Calx of Copper, and silymarin (used as a standard hepatoprotective agent). Hepatotoxicity was induced in the ATD, ATD+Calx of Copper, and silymarin groups by administering a combination of isoniazid, rifampicin, and pyrazinamide for 25 days. Calx of Copper and silymarin were orally administered at doses of 6.17 mg/kg and 12.33 mg/kg, and 300 mg/kg b.w, respectively, in their respective groups. Liver function markers, including serum transaminase and alanine Aminotransferase (ALT), were measured at the end of the study. A histopathological examination of liver tissues was also performed. Results: ATDinduced hepatotoxicity was evident through elevated serum SGPT, SGOT, ALT, and ALP levels and histopathological alterations in liver tissue. Co-administration of Calx of Copper significantly reduced SGPT, SGOT, ALT, and ALP (p\<0.05) and improved liver histopathological changes compared to the ATD group. The hepatoprotective effect of Calx of Copper was comparable to that of silymarin. Conclusion: Copper calx demonstrated significant hepatoprotective activity against ATD-induced hepatotoxicity in rats, as evidenced by normalizing liver function markers and histopathological improvements. These findings suggest that Calx of Copper may be a promising adjuvant therapy for mitigating liver damage associated with anti-tubercular drug treatment.

}, keywords = {Anti-Tubercular, Antioxidant, Copper Calx, Hepatotoxicity, Rat}, doi = {10.5530/pres.15.4.085}, author = {Mohammad Sharique and Hariprasad M.G and Moqbel Ali Moqbel Redhwan and Ashish Jain and Shambhavi S and Mamatha A and Niranjana} }