@article {1010, title = {Analgesic, Anti-inflammatory, and Anti-pyretic Activities of Crinum pedunculatum R.Br. Bulb Extracts}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {December 2021}, pages = {24-29}, type = {Original Article}, chapter = {24}, abstract = {

Background: Crinum pedunculatum R.Br. bulbs are used for the topical management of inflammation by traditional healers in the southern region of Ghana. Objectives: This study aims to assess the analgesic, anti-inflammatory, and anti-pyretic activities of different solvent extracts of Crinum pedunculatum. Methods: The analgesic, anti-inflammatory, and anti-pyretic activities of the bulb extracts of Crinum pedunculatum were determined in rats at doses of 100, 200, and 400 mg/kg. The acetic acid induced writhing test was used to determine the analgesic activity, carrageenan was employed to determine the anti-inflammatory activity, and Brewer{\textquoteright}s yeast-induced pyrexia was studied to evaluate the extract{\textquoteright}s anti-pyretic activity. Results: All solvent extracts of Crinum pedunculatum significantly decreased (P \< 0.001) the frequency of writhing in rats at all doses with 400 mg/kg of the ethanolic extract showing a 98\% inhibition comparable to that obtained with diclofenac sodium at 94\%. These extracts also caused the inhibition of the increase in paw diameter induced by the administration of carrageenan with 400 mg/kg of the ethyl acetate extract of Crinum pedunculatum causing a 97\% inhibition of paw oedema. All doses (100, 200, and 400 mg/kg) of the methanol extract caused a significant decrease (P \< 0.0001) in the temperature of rats induced via the administration of yeast with ethanol and ethyl acetate extracts also showed a significant reduction (P \< 0.001) in rectal temperature. Conclusion: These results obtained indicate that the methanolic, ethanolic, and ethyl acetate extracts of Crinum pedunculatum R.Br. possess analgesic, anti-inflammatory, and antipyretic activities.

}, keywords = {Analgesic, Anti-inflammatory, Anti-pyretic, Crinum pedunculatum, Rats.}, doi = {10.5530/pres.14.1.5}, url = {https://phcogres.com/fulltext/v14i1/105530pres1415.html}, author = {Peace Doe and Cynthia Amaning Danquah and Kwasi Adomako Ohemeng and Ako Ernest Opare and Ahmed Sharif and Dorcas Akua-Abora and Asamoah Kwame Akuoko and Aaron Kpabitey and Emmanuel Quarshie and Oliver Opoku Asante and Elvis Kwadwo Amponsah and Mariyana Mutwaliku and Charlotte Nuro-Brefo and Micheal Ofori} }