@article {1005, title = {Preventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-19}, journal = {Pharmacognosy Reviews}, volume = {13}, year = {2021}, month = {October 2021}, pages = {173-191}, type = {Review Article}, chapter = {173}, abstract = {

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus {\textquotedblleft}Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2){\textquotedblright}. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale are now targeting approaches globally as a preventive care against SARS-CoV-2. Aim: This review is primarily focused on to deliver a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Experimental procedure: In this study, science mapping tool Bibliometrix R-package was used to perform bibliometric analysis and building data matrices for keywords co-occurrence investigation, country-wise scientific production; collaboration between the countries worldwide, co-word analysis on topic {\textquotedblleft}keywords associated with SARS-CoV-2 and medicinal plants{\textquotedblright}. Results and Conclusion: Our findings is to deliver a concise knowledge about the coronaviridae family, pathophysiology, possible targets for managing the SARS-CoV-2, in addition to potential medicinal plants and their phytoconstituents against COVID-19. Target-specific inflammatory pathways due to post infection of SARS e.g. NLRP3, p38-MAPK, Metallopeptidase Domain 17; endocytosis pathways e.g. Clathrin, HMGB1 pathways are primarily highlighted along with relevant interleukins and cytokines, which directly/indirectly triggering to immune system and play a significant role. Based on selective pathways and potential lead, the outcome of our elaborated study put forward selected Indian medicinal plants that hold a very high probability as preventive care in this global crisis.

}, keywords = {Biblioshiny, Coronavirus, COVID-19, Medicinal plants, Phytoconstituents, SARS-CoV-2}, doi = {10.5530/pres.13.4.10}, author = {Neelesh Kumar Nema and Ghouse Modin Nabeesab Mamdapur and Smitha Sarojam and Swapnil Devidas Khamborkar and Linson Cheruveettil Sajan and Sachithra Sabu and Baby Kumaranthara Chacko and Viju Jacob} }