@article {918, title = {A Study of the Anti-inflammatory Effect of the Leaves of Psidium guajava Linn. on Experimental Animal Models}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {November 2010}, pages = {313-317}, type = {Original Article}, chapter = {313}, abstract = {

Introduction : The aim is to study the anti-inflammatory effect of the ethanolic extract of the leaves of Psidium guajava (PGE) on experimental animal models. Materials and Methods : Fresh leaves were collected, air-dried, powdered, and percolated in 95\% ethanol. Acute toxicity test was done according to OECD guidelines. Four groups of animals of either sex, weighing 150-200g of the species Rattus norvegicus were taken for the study (n = 6). Group A was taken as control (3\% gum acacia in 10 mL/kg body weight), Group B as test group (PGE 250 mg/kg body weight), Group C as test group (PGE 500 mg/kg body weight), and Group D as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema, subacute inflammation by Granuloma pouch method, and chronic inflammation by Freund{\textquoteright}s adjuvant-induced arthritis method. Statistical analysis was done by one-way analysis of variance followed by multiple comparison tests. Results : In acute inflammation, there was significant inhibition of paw edema in Groups B, C, and D in comparison with Group A (P \< 0.05). In subacute inflammation, there was significant inhibition of exudate formation in Groups B, C, and D in comparison to Group A (P \< 0.05). In chronic inflammation, there was significant inhibition of paw edema and inhibition of weight reduction in Groups B, C, and D compared with Group A. Downregulation of arthritis index was also significant in Groups B, C, and D in comparison with Group A (P \< 0.05). Conclusion : The ethanolic extract of PGE has significant anti-inflammatory activity.

}, keywords = {Anti-inflammatory, Arthritis, Carrageenan, Granuloma, Psidium guajava}, doi = {10.4103/0974-8490.72331}, author = {Sarmistha Dutta and Swarnamoni Das} }