@article {861, title = {Anti-leukemia Activity of Methanolic Extracts of Lantana camara}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {274-279}, type = {Original Article}, chapter = {274}, abstract = {

Anticancer effect of Lantana camara{\textquoteright}s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 {\textpm} 53.08 μg/ml; leaf, 394.41 {\textpm} 99.73 μg/ml; p \> 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 {\textpm} 3.60 μg/ml; p \< 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara{\textquoteright}s root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.

}, keywords = {anticancer, Cell Culture, Jurkat Cell Line, Lantana camara, MTT assay}, doi = {Nil}, author = {Badakhshan Mahdi Pour and Sreenivasan Sasidharan and Rameshwar Naidu Jegathambigai and Ramanathan Surash} } @article {899, title = {A Comparative Study: Antimicrobial Activity of Methanol Extracts of Lantana camara Various Parts}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {348-351}, type = {Original Article}, chapter = {348}, abstract = {

Finding new resources of antibiotics based on natural products used by traditional practitioners was the main aim to study extracts of root, stem, leaf, flower and fruit of Lantana camara L. (Verbenaceae), a medicinal plant available in Malaysia. A panel of organisms including 10 bacteria and 5 fungi were treated by L. camara extracts of different parts based on disk diffusion method and broth microdilution technique. The leaf extract presented the highest antibiotic effect among all parts of plant especially against Gram positive Bacillus cereus (zone of inhibition 13.0 {\textpm} 0.0 mm, MIC/MBC 9.4 {\textpm} 4.4 mg/ml) and Gram negative Salmonella typhi (zone of inhibition 13.5 {\textpm} 2.1 mm, MIC/MBC 12.5 {\textpm} 0.0 mg/ml). In conclusion, this study may support the conventional use of leaf extract of L. camara in some infectious gastroenteritis disorders, a potential subject to further isolation and identification as a supply of antibacterial substances.

}, keywords = {Antimicrobial activity, Broth Microdilution, Gastrointestinal Diseases, Lantana camara, Minimum inhibitory concentration, Zone of Inhibition}, doi = {Nil}, author = {Badakhshan Mahdi Pour and Sasidharan Srinivasan and Rameshwar Naidu Jegathambigai and Ramanathan Suresh} }