@article {839, title = {Effect of Celastrus paniculatus seed oil (Jyothismati oil) on Acute and Chronic Immobilization Stress Induced In swiss Albino Mice}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {July 2010}, pages = {169-174}, type = {Original Article}, chapter = {169}, abstract = {

Stress alters the homeostasis and is produced by several factors. Immobilization stress induced due to reduced floor area provided for the mobility results in the imbalance of oxidant and antioxidant status. The modern computer savvy world decreases human mobility in the working environment, leading to the formation of oxygen free radicals and if left untreated might result in severe health problems like hypertension, cardiovascular disease, premature aging and brain dysfunction. Hence, modern medicines rely upon the medicinal plants for some drugs with zero side effects. In this context, Jyothismati oil (JO), extracted from Celastrus paniculatus seeds, was used to treat acute and chronic immobilization induced experimentally. C. paniculatus plant is considered to be rich in antioxidant content and so the seed oil extract{\textquoteright}s efficacy was tested against immobilization stress in albino mice. The animals were kept in a restrainer for short and long durations, grouped separately and fed with the drug. Animals were sacrificed and the samples were analyzed. The antioxidant enzyme levels of the animals regained and markedly increased in the acute and chronic immobilized groups, respectively. The results suggested that the extract of C. paniculatus seed was highly efficacious in reducing the stress induced by least mobility for hours.

}, keywords = {Antioxidants, Celastrus paniculatus, Free radicals, Oxidative damage}, doi = {10.4103/0974-8490.65512}, author = {George Lekha and Karthik Mohan and Irudhaya Arockia Samy} } @article {927, title = {Antioxidative Effect of Trichosanthes tricuspidata Root Extract on Sildenafil Induced Migraine in Albino Mice}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {402-405}, type = {Original Article}, chapter = {402}, abstract = {

Migraine is considered a neurovascular disease involving the dilatation of cerebral arteries. Because of their dual role in modulating neuronal and vascular events, neuropeptides have been implied to be of importance in migraine pathophysiology. It is a highly prevalent disorder which manifests clinically as moderate to severe or severe headache attacks with frequent frontotemporal unilateral location and associated symptoms. The disability of migraine results in considerable economic and social losses .Nitric oxide, a short lived vasodilator and weak oxygen radical has been implicated in the genesis of migraine headaches. Hence the role of all enzymic and non enzymic antioxidants becomes in evitable in the treatment of migraine. Trichosanthes tricuspidata{\textquoteright}s (red apple gourd) antioxidant effect was tested over Sildenafil induced migraine in female albino mice. The levels of antioxidant enzymes such as super oxide dismutase (SOD), lipid peroxidase(LPO), catalase(CAT) and glutahione peroxidase(GPx) were more promising in the treatment group fed with the root extract of Trichosanthes tricuspidata.

}, keywords = {Nitric oxide, Oxygen radical, Sildenafil, Stress}, doi = {Nil}, author = {Nithiya .P and Karthik Mohan} }