@article {802, title = {Antihyperlipidemic Potential of Albizia amara (Roxb) Boiv. Bark Against Triton X-100 Induced Hyperlipidemic Condition in Rats}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, abstract = {

Background: The plant Albizia amara (Roxb.) Boiv. bark was used in traditional medical practices of India to treat cardiovascular diseases. Hyperlipidemia is the greatest risk factor of coronary heart disease. Objective: The objective of this study was to screen the potential of A. amara against the condition of hyperlipidemia in rats. Materials and Methods: The antihyperlipidemic activity of A. amara ethanolic extract (AAEE) was studied on Triton X-100 induced model of hyperlipidemia in rats. Hyperlipidemia in experimental rats was evidenced by an enhancement in the levels of serum cholesterol, triglycerides (TGs), low density lipoprotein (LDL), very LDL (VLDL) and decrease in high density lipoprotein (HDL). Results: AAEE showed significant antihyperlipidemic effect by lowering the serum levels of biochemical parameters such as a significant reduction in the level of serum cholesterol, TG (104.1 {\textpm} 3.39), LDL (48.2 {\textpm} 2.19), VLDL (20.81 {\textpm} 0.67) and increase in HDL (47.25 {\textpm} 2.05) level with an increase in a dose of AAEE (41.39 {\textpm} 1.24) \< (47.25 {\textpm} 2.05), which was similar to the standard drug atorvastatin. The results of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase also revealed that the plant extract was found to be safe on liver. Histopathological evaluation also revealed the positive effect of the plant extract. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as saponins, glycosides and tannins. The preliminary chemical constituents stood as a strong evidence for the study. Conclusion: Summing up the evidences of the pragmatic study, we can conclude that the extract of A. amara (Roxb.) Boiv. Bark aids in declining the condition of hyperlipidemia in rats.

}, keywords = {Albizia amara, Atorvastatin, Hyperlipidemia, Triton X-100}, doi = {10.4103/0974-8490.138237}, author = {Rohit Gundamaraju and Kim Kah Hwi and Rajeev K Singla and Ravi Chandra Vemuri and Sartaj Banu Mulapalli} } @article {774, title = {Exploiting the Phenomenal Anti-ulcerogenic Potential of Talinum portulacifolium Ethanolic Extract Whole Plant on Albino Rats: The Therapeutic Potential of Chinese Herb-mǎ chǐ xi{\`a}n ke (Portulacaceae)}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {May,2014}, pages = {227-233}, type = {Original Article}, chapter = {227}, abstract = {

Background: Ulcerations have been effecting humans and causing major damage in the gastro intestinal tract. A need for development of a flawless anti-ulcer medication was always in the agenda. Thus, the need to conduct a study was provoked. Objectives: The major objective of the present study is to screen the antiulcer activity of the ethanolic extract of Talinum portulacifolium (Forsk) plant. Materials and Methods: The antiulcer activity of the ethanolic extract of T.Z portulacifolium was performed on albino rats. Gastric ulcers were induced by ethanol, pylorus ligated aspirin and histamine induced ulcer models. Omeprazole was used as a standard drug for comparison. Results: Treatment with the T. portulacifolium plant extract significantly protected the ulceration induced by the three models. The gastric volume, pH of gastric juice, total acidity, free acidity and ulcer index were the parameters estimated and did show significant results. 800 mg/kg extracts of T. portulacifolium did show high significant results as that of standard drug. Percentage protection of 800 mg/kg was 79.9\% and the standard drug-treated group did show 84\%. So was with total acidity (38.1 + 1.45) and free acidity (16.5 + 0.76) Conclusion: The ethanolic extract of T. portulacifolium plant was found to possess a significant antiulcer activity.

}, keywords = {ethanol, Histamine, Omeprazole, Pylorus-ligated aspirin, Talinum portulacifolium}, doi = {10.4103/0974-8490.132600}, author = {Rohit Gundamaraju and Kotla Maheedhar and Kim Kah Hwi} }