@article {655, title = {Bronchodilatory Effect of Ethanolic Extract of the Leaves of Nyctanthes Arbortristis,}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {169-172}, type = {Original Article }, chapter = {169}, abstract = {

Background:Nyctanthes arbortristis\ has been used in traditional medicine for the treatment of asthma and cough.\ Aim:\ In this study, bronchodilatory effect of ethanolic extract of the\ N. arbortristis\ was investigated under\ in vitro\ conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nω-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM (\ P\ \< 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of\ N. arbortristis\ as a bronchodilator in therapeutic treatment of asthma.

}, keywords = {a0 sthma, Ethanolic Eextract Nyctanthes Arbortristis, Tracheal Smooth Muscle}, doi = {10.4103/0974-8490.112422 }, author = {Ramadan B Sopi and Muhammad Feroz Hayat Khan} }