@article {648, title = {Evaluation of Marine Brown Algae Sargassum ilicifolium Extract for Analgesic and Anti-inflammatory Activity}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {146-149}, type = {Original Article }, chapter = {146}, abstract = {

Background\ : The methanolic extract of\ Sargassum ilicifolium\ (Pheophyceae) was used to evaluate its analgesic and anti-inflammatory activity in the present study.\ Materials and Methods:\ Analgesic activity was tested using Acetic acid writhing method and Eddy hot plate method in Male albino mice and Wister rats respectively at a dose level of 1, 10, 50, 100mg/kg p.o. At the same dose, its anti-inflammatory activity was also tested using Carrageenan induced rat paw edema method Result Acetic acid writhing test and Eddy{\textquoteright}s hot plate episodes were significantly and dose dependently reduced. Carrageenan (a standard inflammatory agent) induced paw edema in rats was significantly reduced after intraperitonal administration of methanolic extract.\ Results:\ showed dose dependant significant activity in comparison with standard and control.\ Conclusion:\ Methanolic extracts of the brown seaweeds\ Sargassum ilicifolium\ have potent analgesic and anti-inflammatory activity at moderate doses.

}, keywords = {Acetic acid Writhing, Analgesic, Anti-inflammatory, Carrageenan, Granuloma, Hot Plate, Paw edema, Sargassum Ilicifolium}, doi = {10.4103/0974-8490.112413 }, author = {Chandraraj C Simpi and Channabasappa V Nagathan and Santosh R Karajgi and Navanath V Kalyane} }