@article {633, title = {Anti-arthritic Activity of Ethanolic Extract of Tridax Procumbens (Linn.) in Sprague Dawley Rats}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = { 113-117}, type = {Original Article }, chapter = {113}, abstract = {

Objective:\ To determine the anti-arthritic effect of whole plant ethanolic extract of\ Tridax procumbens\ (Asteraceae) in female Sprague Dawley (SD) rats using the Freund{\textquoteright}s Complete Adjuvant (FCA) model.\ Materials and Methods:\ The plant was collected from different regions of Madurai District, Tamil Nadu, and the phytoconstituents were identified through chemical tests. Ethanol (95\%) was used to obtain the whole plant extraction through Soxhlet extractor. Female SD rats were used for anti-arthritic screening. Arthritis was induced using FCA, and the anti-arthritic effect of the ethanolic extract of\ T. procumbens\ was studied at doses of 250 and 500 mg/kg. The effects were compared with those of indomethacin (10 mg/kg). At the end of the study, the liver enzyme levels were determined and a radiological examination was carried out.\ Result:\ The preliminary phytochemical analysis of the ethanolic extract of\ T. procumbens\ indicated the presence of alkaloids, tannins, flavonoids and saponins.\ T. procumbens\ at 250 and 500 mg/kg significantly inhibited the FCA-induced arthritis in the rats. This was manifested by as a decrease in the paw volume. The arthritic control animals exhibited a significant decrease in body weight compared with control animals without arthritis.\ T. procumbens\ animals showed dose dependent reduction in decrees in body weight and arthritis. At the same time,\ T. procumbens\ significantly altered the biochemical and haematological changes induced by FCA (\ P\ \< 0.05). The anti-arthritic effect of\ T. procumbens\ was comparable with that of indomethacin.\ Conclusion:\ The whole plant extract of\ T. procumbens\ showed significant anti-arthritic activity against FCA-induced arthritis in female SD rats.

}, keywords = {Arthritis, Freund's Complete Adjuvant, T. Procumbens}, doi = { 10.4103/0974-8490.110541}, author = {R Ramesh Petchi and C Vijaya and S Parasuraman} } @article {932, title = {Neuropharmacological activity of Lippia nodifl ora Linn.}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {September 2011}, pages = {194-200}, type = {Original Article}, chapter = {194}, abstract = {

Introduction: In the recent years, plants containing flavonoids have gained much more interest in research area, as they are found to be specific ligands for benzodiazepine receptors. Material and Methods: In our investigation, we evaluated the neuropharmacological profile of petroleum, chloroform and ethanolic extracts of aerial part of Lippia nodiflora Linn. With experimental models using test such as potentiation of diazepam-induced sleeping time, locomotor activity, motor coordination, exploratory behavior pattern, elevated plus maze and maximal electroshock convulsions. Diazepam at doses of 5, 4, and 1 mg/kg served as standard. Results: Results showed that the ethanolic extract of L. nodifl ora at both doses (250 and 500 mg/kg p.o.) and its chloroform extract at a higher dose of 500 mg/kg produced central inhibitory (sedative) effects, anticonvulsant effect and anxiolytic effect in mice. Values were statistically significant (P \< 0.05 and P \< 0.01) when compared to the control group. The petroleum ether extract of plant at both dose levels (250 and 500 mg/kg p.o.) did not produce any central effects. Conclusion: In conclusion, we can say that the ethanolic and chloroform extracts showed the central inhibitory activity due to the presence of fl avonoids and this fact was also supported by the finding that the petroleum ether extract did not show any central effect and flavonoids were not found in it.

}, keywords = {Lippia nodiflora, neuropharmacological activity}, doi = {10.4103/0974-8490.85007}, author = {Kumaresan P Thirupathy and Asish Tulshkar and C Vijaya} }