@article {1521, title = {A Decade of Research on Plant-Based Anticancer Compounds: A Scientometric Analysis}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1395-1397}, type = {Short Communication}, chapter = {1395}, abstract = {

Cancer continues to be one of the leading global health challenges, driving increasing scientific interest in natural and plant-derived therapeutic alternatives. This study presents a scientometric analysis of global research on plant-based anticancer compounds published between 1997 and 2025, with a particular focus on the past decade (2014{\textendash}2023). A total of 279 publications were retrieved from the Web of Science database and analyzed using bibliometric techniques to map publication growth, research hotspots, collaborations, and citation impact. Findings indicate a consistent rise in scholarly output, with a sharp surge after 2017, reflecting the growing integration of phytochemistry, nanotechnology, and oncology. India, China, and the USA emerged as the leading contributors, supported by European and Middle Eastern collaborations. Prominent institutions include Comenius University (Slovakia) and NIPER (India), while key journals such as Journal of Ethnopharmacology and Phytomedicine have served as major publication venues. Keyword analysis revealed evolving themes from classical phytochemical mechanisms (apoptosis, angiogenesis inhibition) to emerging areas such as green nanotechnology, polyherbal synergism, and immunomodulation. Highly cited works emphasize the potential of synergistic phytochemical formulations and nanoparticle mediated delivery systems. Despite encouraging laboratory results, challenges such as assay variability, poor standardization of phytochemicals, and limited clinical translation remain major barriers. Future directions point toward integrating artificial intelligence, omics-based approaches, and sustainable green nanotechnology for advancing phytomedicine. This scientometric overview highlights the growing global emphasis on plant-based anticancer compounds, offering valuable insights for researchers, funding bodies, and policymakers to strengthen translational research in natural product oncology.

}, keywords = {anticancer, Cancer therapy, Medicinal plants, Natural Products, Phytochemicals, Plant-based compounds, Scientometric Analysis}, doi = {10.5530/pres.20250002}, author = {Mueen Ahmed KK and Chaman Sab M} } @article {614, title = {Active Spermatogenesis Induced by a Reiterated Administration of Globularia Alypum L. Aqueous Leaf Extract}, journal = {Pharmacognosy Research}, volume = {4}, year = {2012}, month = {July,2012}, pages = {138-147}, type = {Original Article}, chapter = {138}, abstract = {

Background: Globularia alypum L. (Globulariaceae) is a shrub growing in the Mediterranean basin and known to be used as a popular medicine for its several pharmacological properties against rheumatism, gout, typhoid, intermittent fever, and diabetes. Materials and Methods: The acute and chronic toxicities of a G. alypum L. aqueous leaf extract were studied in animals. Acute toxicity was performed in male and female mice whereas chronic toxicity was realized in male and female rats that orally received the drug at the doses of 300 and 600 mg/kg/24 h for 30 days. Results: Acute toxicity showed that the extract, administered by the oral route, does not induce any mortality even for a dose of 10,000 mg/kg. Administered by the intra-peritoneal route to female and male mice, the LD50 of the extract was found to be of 2750 and 2550 mg/kg, respectively. A chronic toxicity study showed that, compared to the control groups that only received the vehicle (water), the drugs affects weight growth (effects more pronounced in female than in male rats), some organs weight after autopsy, hematological and biochemical parameters and histology of some principal organs (lungs: histological grades I to II pulmonary hypertension (PHT), respiratory distress syndrome (ARDS), and lymphoid hyperplasia; esophagus: thinning down of esophageal wall, atrophic muscular coat). The most important finding of the study was the recorded active spermatogenesis induced by the reiterated administrations of the drug that was confirmed by reducing the administered dose and the period of treatment (100 mg/kg/24 hr\ for 15 days). Conclusion: It is suggested that the G. alypum L. leaf extract contains active substances with androgenic properties that could be used in human therapy.

}, keywords = {Active spermatogenesis, Acute and chronic toxicity, Androgenic properties, Globularia alypum L.}, doi = {10.4103/0974-8490.99073}, author = {Badreddine Fehri and Jean-Marc Aiache and Mueen Ahmed KK} }