@article {604, title = {Flavonoid Glycosides and Pharmacological Activity of Amphilophium Paniculatum}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {January 2013}, pages = {17-21}, type = {Original Article }, chapter = {17}, abstract = {

Background:\ Nothing is reported on\ Amphilophium paniculatum\ (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of\ Amphilophium paniculatum,\ grown in Egypt, in addition to pharmacological evaluation.\ Materials and Methods:\ Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of\ A. paniculatum\ leaves.\ Results:\ Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1{\textrightarrow}2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70\% ethanol crud extract and its successive chloroform, ethyl acetate, and 100\% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD\ 50\ ) revealed that the different extracts were safe.

}, keywords = {Amphilophium Paniculatum, Bignoniaceae, Flavonoids, Pharmacology}, doi = {10.4103/0974-8490.105643 }, author = {Mahmoud I Nassar and El-Sayed A Aboutabl and Dina M Eskander and Mary H Grace and Ezzel-Din A EL-Khrisy and Amany A Sleem} } @article {930, title = {Secondary Metabolites and Bioactivities of Myrtus communis}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {January 2011}, pages = {325-329}, type = {Original Article}, chapter = {325}, abstract = {

Background: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. Methods: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7\% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid. Results: Determination of the median lethal dose (LD 50 ) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. Conclusion : Administration of extracts of M. communis leaves could be safe at the dose used in this study.

}, keywords = {Anti-inflammatory, Antihyperglycemic, Antinociceptive, LD 50, Myrtus communis, Volatile oil}, doi = {10.4103/0974-8490.75449}, author = {Mahmoud I Nassar and El-Sayed A Aboutabl and Rania F Ahmed and Ezzel-Din A EL-Khrisy and Khaled M Ibrahim and Amany A Sleem} }