@article {600, title = {Anti-atherogenic and Anti-ischemic Potentials of Croton Membranaceus Observed During Sub-chronic Toxicity Studies}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {January 2013}, pages = {10-16}, type = {Original Article }, chapter = {10}, abstract = {

Background\ :\ Croton membranaceus\ (CM) is used for benign prostate hyperplasia treatment.\ Objective\ : Sub-chronic toxicity studies are non-existent and provided the basis for this study.\ Materials and Methods\ : 90 days oral administration of a low dose (LD) (30 mg/kg b. wt.), medium dose (MD) (150 mg/kg b. wt.), and high dose (HD) (300 mg/kg b. wt.)\ CM\ aqueous root extract to 3 groups (n=6 each) of male Sprague-Dawley rats, alongside a control group, was undertaken. Urinalysis, hepato-renal function tests, lipid profile, cardiac enzymes, and routine hematology tests were performed.\ Results\ : Triglyceride levels (C=1.05{\textpm}0.19, LD=0.64{\textpm}0.08, MD=0.55{\textpm}0.04, HD=0.50{\textpm}0.02 mmol/L) were significantly reduced (P\<0.05). Very low density lipoprotein (C=0.48{\textpm}0.09, LD=0.29{\textpm}0.04, MD=0.25{\textpm}0.02, HD=0.23{\textpm}0.01 mmol/L) decreased significantly (P\<0.05). Cardiac enzymes-creatinine kinase (C=568{\textpm}172, LD=315{\textpm}79, MD=441{\textpm}209, HD=286{\textpm}81 IU/L) decreased markedly (P\<0.05) alongside lactate dehydrogenase (C=2675{\textpm}875, LD=1667{\textpm}1229, MD=1186{\textpm}442, HD=855{\textpm}239 IU/L) (P\<0.05).\ Conclusion\ :\ C. membranaceus\ aqueous root extract is non-toxic but demonstrates anti-atherogenic and anti-ischemic potentials.

}, keywords = {Anti-atherogenic, Anti-ischemic, Croton Membranaceus, Sub-chronic, Toxicity}, doi = {10.4103/0974-8490.105640}, author = {Dan K Afriyie and George A Asare and Kwasi Bugyei and Isaac Asiedu-Gyekye and Ben A Gyan and Samuel Adjei and Phyllis Addo and Archibald Sittie and Alexander K Nyarko} }