@article {701, title = {The Efficacy of Ginger Added to Ondansetron for Preventing Postoperative Nausea and Vomiting in Ambulatory Surgery}, journal = {Pharmacognosy Research}, volume = {6}, year = {2014}, month = {December,2013}, pages = {52-57}, type = {Original Article}, chapter = {52}, abstract = {

Background: Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. Objective: The study was carried out to compare the effi cacy of ginger (Zingiber offi cinale) added to Ondansetron in preventing PONV after ambulatory surgery. Materials and Methods: It was a prospective, double blinded, and randomized controlled study. From March 2008 to July 2010, 100 adult patients of either sex, aged 20-45, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A[(n = 50) receiving (IV) Ondansetron (4 mg) and two capsules of placebo] and Group B[(n = 50) receiving IV Ondansetron (4 mg) and two capsules of ginger] simultaneously one hour prior to induction of general anaesthesia (GA) in a double-blind manner. One ginger capsule contains 0.5 gm of ginger powder. Episodes of PONV were noted at 0.5h, 1h, 2h, 4h, 6h, 12h and 18h post- operatively. Statistical Analysis and Results: Statistically signifi cant difference between groups A and B (P \< 0.05), was found showing that ginger ondansetron combination was superior to plain Ondansetron as antiemetic regimen for both regarding frequency and severity. Conclusion: Prophylactic administration of ginger and ondansetron signifi cantly reduced the incidence of postoperative nausea and vomiting compared to ondansetron alone in patients undergoing day care surgery under general anaesthesia.

}, doi = {10.4103/0974-8490.122918}, author = {Pragnadyuti Mandal and Anjan Das and Saikat Majumdar and Tapas Bhattacharyya and Tapobrata Mitra and Ratul Kundu} }