@article {657, title = {Anti-ulcer and Ulcer Healing Potentials of Musa Sapientum Peel Extract in the Laboratory Rodents}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {173-178}, type = {Original Article }, chapter = {173}, abstract = {

Background:\ This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of\ Musa sapientum\ peel in the laboratory rats.\ Materials and Methods:\ Methanol extract of the peels on\ Musa sapientum\ (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats.\ Results:\ The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P\ <= 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group.\ Conclusion:\ The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

}, keywords = {Anti-ulcer, Musa sapientum, Peptic Ulcer, Ulcer Healing}, doi = {10.4103/0974-8490.112423}, author = {Samuel Adetunji Onasanwo and Benjamin Obukowho Emikpe and Austin Azubuike Ajah and Taiwo Olayemi Elufioye} }